TY - JOUR
T1 - Cortical reactivations during sleep spindles following declarative learning
AU - Jegou, Aude
AU - Schabus, Manuel
AU - Gosseries, Olivia
AU - Dahmen, Brigitte
AU - Albouy, Geneviève
AU - Desseilles, Martin
AU - Sterpenich, Virginie
AU - Phillips, Christophe
AU - Maquet, Pierre
AU - Grova, Christophe
AU - Dang-Vu, Thien Thanh
N1 - Funding Information:
This work was supported by the Belgian National Funds for Scientific Research (FRS-FNRS) , the University and University Hospital of Liège (Belgium). T.T.D.V. was also supported by the Natural Sciences and Engineering Research Council of Canada ( RGPIN 436006-2013 ), the Canadian Institutes of Health Research ( MOP 142191 , PJT 153115 and PJT 156125 ), the Fonds de Recherche du Québec – Santé ; the Canada Foundation for Innovation and Concordia University . AJ was supported by a Perform centre master's scholarship. M.S. was supported by an Erwin Schrödinger fellowship of the Austrian Science Fund (FWF; J2470-B02 ). O.G was also supported by the European Union’s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2). We thank all the participants for their participation in this study.
Funding Information:
This work was supported by the Belgian National Funds for Scientific Research (FRS-FNRS), the University and University Hospital of Liège (Belgium). T.T.D.V. was also supported by the Natural Sciences and Engineering Research Council of Canada (RGPIN 436006-2013), the Canadian Institutes of Health Research (MOP 142191, PJT 153115 and PJT 156125), the Fonds de Recherche du Québec – Santé; the Canada Foundation for Innovation and Concordia University. AJ was supported by a Perform centre master's scholarship. M.S. was supported by an Erwin Schrödinger fellowship of the Austrian Science Fund (FWF; J2470-B02). O.G was also supported by the European Union's Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2). We thank all the participants for their participation in this study.
Publisher Copyright:
© 2019 Elsevier Inc.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/7/15
Y1 - 2019/7/15
N2 - Increasing evidence suggests that sleep spindles are involved in memory consolidation, but few studies have investigated the effects of learning on brain responses associated with spindles in humans. Here we used simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) during sleep to assess haemodynamic brain responses related to spindles after learning. Twenty young healthy participants were scanned with EEG/fMRI during (i) a declarative memory face sequence learning task, (ii) subsequent sleep, and (iii) recall after sleep (learning night). As a control condition an identical EEG/fMRI scanning protocol was performed after participants over-learned the face sequence task to complete mastery (control night). Results demonstrated increased responses in the fusiform gyrus both during encoding before sleep and during successful recall after sleep, in the learning night compared to the control night. During sleep, a larger response in the fusiform gyrus was observed in the presence of fast spindles during the learning as compared to the control night. Our findings support a cortical reactivation during fast spindles of brain regions previously involved in declarative learning and subsequently activated during memory recall, thereby promoting the cortical consolidation of memory traces.
AB - Increasing evidence suggests that sleep spindles are involved in memory consolidation, but few studies have investigated the effects of learning on brain responses associated with spindles in humans. Here we used simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) during sleep to assess haemodynamic brain responses related to spindles after learning. Twenty young healthy participants were scanned with EEG/fMRI during (i) a declarative memory face sequence learning task, (ii) subsequent sleep, and (iii) recall after sleep (learning night). As a control condition an identical EEG/fMRI scanning protocol was performed after participants over-learned the face sequence task to complete mastery (control night). Results demonstrated increased responses in the fusiform gyrus both during encoding before sleep and during successful recall after sleep, in the learning night compared to the control night. During sleep, a larger response in the fusiform gyrus was observed in the presence of fast spindles during the learning as compared to the control night. Our findings support a cortical reactivation during fast spindles of brain regions previously involved in declarative learning and subsequently activated during memory recall, thereby promoting the cortical consolidation of memory traces.
KW - Adult
KW - Cerebral Cortex/physiology
KW - Electroencephalography
KW - Female
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Memory Consolidation/physiology
KW - Mental Recall/physiology
KW - Sleep Stages/physiology
KW - Young Adult
UR - http://www.scopus.com/inward/record.url?scp=85063758399&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2019.03.051
DO - 10.1016/j.neuroimage.2019.03.051
M3 - Article
C2 - 30928690
AN - SCOPUS:85063758399
SN - 1053-8119
VL - 195
SP - 104
EP - 112
JO - NeuroImage
JF - NeuroImage
ER -