Cortical reactivations during sleep spindles following declarative learning

Aude Jegou, Manuel Schabus, Olivia Gosseries, Brigitte Dahmen, Geneviève Albouy, Martin Desseilles, Virginie Sterpenich, Christophe Phillips, Pierre Maquet, Christophe Grova, Thien Thanh Dang-Vu

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

Increasing evidence suggests that sleep spindles are involved in memory consolidation, but few studies have investigated the effects of learning on brain responses associated with spindles in humans. Here we used simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) during sleep to assess haemodynamic brain responses related to spindles after learning. Twenty young healthy participants were scanned with EEG/fMRI during (i) a declarative memory face sequence learning task, (ii) subsequent sleep, and (iii) recall after sleep (learning night). As a control condition an identical EEG/fMRI scanning protocol was performed after participants over-learned the face sequence task to complete mastery (control night). Results demonstrated increased responses in the fusiform gyrus both during encoding before sleep and during successful recall after sleep, in the learning night compared to the control night. During sleep, a larger response in the fusiform gyrus was observed in the presence of fast spindles during the learning as compared to the control night. Our findings support a cortical reactivation during fast spindles of brain regions previously involved in declarative learning and subsequently activated during memory recall, thereby promoting the cortical consolidation of memory traces.

langue originaleAnglais
Pages (de - à)104-112
Nombre de pages9
journalNeuroImage
Volume195
Les DOIs
Etat de la publicationPublié - 15 juil. 2019

Financement

This work was supported by the Belgian National Funds for Scientific Research (FRS-FNRS) , the University and University Hospital of Liège (Belgium). T.T.D.V. was also supported by the Natural Sciences and Engineering Research Council of Canada ( RGPIN 436006-2013 ), the Canadian Institutes of Health Research ( MOP 142191 , PJT 153115 and PJT 156125 ), the Fonds de Recherche du Québec – Santé ; the Canada Foundation for Innovation and Concordia University . AJ was supported by a Perform centre master's scholarship. M.S. was supported by an Erwin Schrödinger fellowship of the Austrian Science Fund (FWF; J2470-B02 ). O.G was also supported by the European Union’s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2). We thank all the participants for their participation in this study. This work was supported by the Belgian National Funds for Scientific Research (FRS-FNRS), the University and University Hospital of Liège (Belgium). T.T.D.V. was also supported by the Natural Sciences and Engineering Research Council of Canada (RGPIN 436006-2013), the Canadian Institutes of Health Research (MOP 142191, PJT 153115 and PJT 156125), the Fonds de Recherche du Québec – Santé; the Canada Foundation for Innovation and Concordia University. AJ was supported by a Perform centre master's scholarship. M.S. was supported by an Erwin Schrödinger fellowship of the Austrian Science Fund (FWF; J2470-B02). O.G was also supported by the European Union's Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2). We thank all the participants for their participation in this study.

Bailleurs de fondsNuméro du bailleur de fonds
Canada Foundation for Innovation and Concordia University
University
University Hospital of Liège
Horizon 2020 Framework Programme785907
Canadian Institutes of Health ResearchMOP 142191, PJT 153115, PJT 156125
Natural Sciences and Engineering Research Council of CanadaRGPIN 436006-2013
Fonds de Recherche du Québec - Santé
Canada foundation for innovation
Austrian Science FundJ2470-B02
Fonds De La Recherche Scientifique - FNRS
Concordia University
Université de Liège

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