Résumé
Increasing evidence suggests that sleep spindles are involved in memory consolidation, but few studies have investigated the effects of learning on brain responses associated with spindles in humans. Here we used simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) during sleep to assess haemodynamic brain responses related to spindles after learning. Twenty young healthy participants were scanned with EEG/fMRI during (i) a declarative memory face sequence learning task, (ii) subsequent sleep, and (iii) recall after sleep (learning night). As a control condition an identical EEG/fMRI scanning protocol was performed after participants over-learned the face sequence task to complete mastery (control night). Results demonstrated increased responses in the fusiform gyrus both during encoding before sleep and during successful recall after sleep, in the learning night compared to the control night. During sleep, a larger response in the fusiform gyrus was observed in the presence of fast spindles during the learning as compared to the control night. Our findings support a cortical reactivation during fast spindles of brain regions previously involved in declarative learning and subsequently activated during memory recall, thereby promoting the cortical consolidation of memory traces.
| langue originale | Anglais |
|---|---|
| Pages (de - à) | 104-112 |
| Nombre de pages | 9 |
| journal | NeuroImage |
| Volume | 195 |
| Les DOIs | |
| état | Publié - 15 juil. 2019 |
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Cortical reactivations during sleep spindles following declarative learning. / Jegou, Aude; Schabus, Manuel; Gosseries, Olivia; Dahmen, Brigitte; Albouy, Geneviève; Desseilles, Martin; Sterpenich, Virginie; Phillips, Christophe; Maquet, Pierre; Grova, Christophe; Dang-Vu, Thien Thanh.
Dans: NeuroImage, Vol 195, 15.07.2019, p. 104-112.Résultats de recherche: Contribution à un journal/une revue › Article
TY - JOUR
T1 - Cortical reactivations during sleep spindles following declarative learning
AU - Jegou, Aude
AU - Schabus, Manuel
AU - Gosseries, Olivia
AU - Dahmen, Brigitte
AU - Albouy, Geneviève
AU - Desseilles, Martin
AU - Sterpenich, Virginie
AU - Phillips, Christophe
AU - Maquet, Pierre
AU - Grova, Christophe
AU - Dang-Vu, Thien Thanh
PY - 2019/7/15
Y1 - 2019/7/15
N2 - Increasing evidence suggests that sleep spindles are involved in memory consolidation, but few studies have investigated the effects of learning on brain responses associated with spindles in humans. Here we used simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) during sleep to assess haemodynamic brain responses related to spindles after learning. Twenty young healthy participants were scanned with EEG/fMRI during (i) a declarative memory face sequence learning task, (ii) subsequent sleep, and (iii) recall after sleep (learning night). As a control condition an identical EEG/fMRI scanning protocol was performed after participants over-learned the face sequence task to complete mastery (control night). Results demonstrated increased responses in the fusiform gyrus both during encoding before sleep and during successful recall after sleep, in the learning night compared to the control night. During sleep, a larger response in the fusiform gyrus was observed in the presence of fast spindles during the learning as compared to the control night. Our findings support a cortical reactivation during fast spindles of brain regions previously involved in declarative learning and subsequently activated during memory recall, thereby promoting the cortical consolidation of memory traces.
AB - Increasing evidence suggests that sleep spindles are involved in memory consolidation, but few studies have investigated the effects of learning on brain responses associated with spindles in humans. Here we used simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) during sleep to assess haemodynamic brain responses related to spindles after learning. Twenty young healthy participants were scanned with EEG/fMRI during (i) a declarative memory face sequence learning task, (ii) subsequent sleep, and (iii) recall after sleep (learning night). As a control condition an identical EEG/fMRI scanning protocol was performed after participants over-learned the face sequence task to complete mastery (control night). Results demonstrated increased responses in the fusiform gyrus both during encoding before sleep and during successful recall after sleep, in the learning night compared to the control night. During sleep, a larger response in the fusiform gyrus was observed in the presence of fast spindles during the learning as compared to the control night. Our findings support a cortical reactivation during fast spindles of brain regions previously involved in declarative learning and subsequently activated during memory recall, thereby promoting the cortical consolidation of memory traces.
KW - Consolidation
KW - EEG/fMRI
KW - Memory
KW - Oscillations
KW - Replay
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=85063758399&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2019.03.051
DO - 10.1016/j.neuroimage.2019.03.051
M3 - Article
C2 - 30928690
AN - SCOPUS:85063758399
VL - 195
SP - 104
EP - 112
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
ER -