An efficient procedure for the copper-catalyzed cross-coupling between a broad range of cyanamides and iodoalkenes is reported. Upon reaction with catalytic amounts of copper(I) iodide and 2,2′-bisimidazole in the presence of cesium carbonate in DMF at 80 °C, a fast, regioselective, and stereoretentive cross-coupling occurs. This reaction, which was found to have a broad substrate scope, provides the first general entry to N-alkenylcyanamides, building blocks that hold great synthetic potential.
Plateforme technologique Caracterisation physico-chimiques
Equipement/installations: Plateforme technolgique
Nitelet, A. (Créateur), WOUTERS, J. (Contributeur), Dewez, D. F. (Créateur) & Evano, G. (Créateur), University of Namur, 1 déc. 2017
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