The combination of bioresorbable and biodegradable hydrophilic polysaccharides with biodegradable hydrophobic polyester chains to form totally biodegradable, nonionic brushlike amphiphilic graft copolymers useful as surfactants has been investigated. In fact, a totally controlled and original three-step procedure is described which gives access to a wide range of poly(ε-caprolactone)-grafted dextran copolymer compositions. It consists of the reversible protection of the hydroxyl groups of the polysaccharide backbone by silylation, followed by the ring-opening polymerization of ε-caprolactone initiated by the free remaining hydroxyl groups of the partially silylated dextran in the presence of aluminum and tin-based catalysts. The last step relies upon the removal of silylating groups under mild acidic conditions yielding the desired amphiphilic graft copolymers.
|Pages (de - à)||6713-6721|
|Nombre de pages||9|
|Numéro de publication||18|
|Etat de la publication||Publié - 5 sept. 2000|