Comparison of the effects of propofol and pentobarbital on left ventricular adaptation to an increased afterload

Philippe Kolh, Bernard Lambermont, Alexandre Ghuysen, Vincent Tchana-Sato, Jean-Michel Dogné, Vincent D'Orio, Paul Gerard, Robert Larbuisson, Raymond Limet

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

The purpose of this study was to compare the hemodynamic effects of pentobarbital and propofol and their effects on cardiovascular adaptation to an abrupt increase in left ventricular afterload. Experiments were performed in 12 open-chest pigs instrumented for measurement of aortic pressure and flow, and left ventricular pressure and volume. In one group (n = 6), anesthesia was obtained with sodium pentobarbital (3 mg x kg(-1) x h(-1)), and, in the second group B (n = 6), with propofol (10 mg x kg(-1) x h(-1)). Both groups received sufentanil (0.5 microg x kg(-1) x h(-1)) and pancuronium bromide (0.1 mg x kg(-1)). Left ventricular function was assessed by the slope of end-systolic pressure-volume relationship and stroke work. After baseline recordings, left ventricular afterload was increased by aortic banding. The cardiovascular adaptations triggered by the aortic banding, such as tachycardia, vasoconstriction, and augmentation of myocardial contractility were prevented with propofol, suggesting interference with the baroreflex. Increase in left ventricular afterload decreased mechanical efficiency, regardless of anesthetic agent. These results showed that pentobarbital at 3 mg x kg(-1) x h(-1) has less deleterious hemodynamic effects than propofol at 10 mg x kg(-1) x h(-1).
langue originaleAnglais
Pages (de - à)294-301
Nombre de pages8
journalJournal of cardiovascular pharmacology
Volume44
Numéro de publication3
étatPublié - sept. 2004

Empreinte digitale

Propofol
Pentobarbital
Hemodynamics
Sufentanil
Pancuronium
Baroreflex
Ventricular Pressure
Vasoconstriction
Left Ventricular Function
Tachycardia
Stroke Volume
Anesthetics
Arterial Pressure
Swine
Thorax
Anesthesia
Blood Pressure

Citer ceci

Kolh, P., Lambermont, B., Ghuysen, A., Tchana-Sato, V., Dogné, J-M., D'Orio, V., ... Limet, R. (2004). Comparison of the effects of propofol and pentobarbital on left ventricular adaptation to an increased afterload. Journal of cardiovascular pharmacology, 44(3), 294-301.
Kolh, Philippe ; Lambermont, Bernard ; Ghuysen, Alexandre ; Tchana-Sato, Vincent ; Dogné, Jean-Michel ; D'Orio, Vincent ; Gerard, Paul ; Larbuisson, Robert ; Limet, Raymond. / Comparison of the effects of propofol and pentobarbital on left ventricular adaptation to an increased afterload. Dans: Journal of cardiovascular pharmacology. 2004 ; Vol 44, Numéro 3. p. 294-301.
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abstract = "The purpose of this study was to compare the hemodynamic effects of pentobarbital and propofol and their effects on cardiovascular adaptation to an abrupt increase in left ventricular afterload. Experiments were performed in 12 open-chest pigs instrumented for measurement of aortic pressure and flow, and left ventricular pressure and volume. In one group (n = 6), anesthesia was obtained with sodium pentobarbital (3 mg x kg(-1) x h(-1)), and, in the second group B (n = 6), with propofol (10 mg x kg(-1) x h(-1)). Both groups received sufentanil (0.5 microg x kg(-1) x h(-1)) and pancuronium bromide (0.1 mg x kg(-1)). Left ventricular function was assessed by the slope of end-systolic pressure-volume relationship and stroke work. After baseline recordings, left ventricular afterload was increased by aortic banding. The cardiovascular adaptations triggered by the aortic banding, such as tachycardia, vasoconstriction, and augmentation of myocardial contractility were prevented with propofol, suggesting interference with the baroreflex. Increase in left ventricular afterload decreased mechanical efficiency, regardless of anesthetic agent. These results showed that pentobarbital at 3 mg x kg(-1) x h(-1) has less deleterious hemodynamic effects than propofol at 10 mg x kg(-1) x h(-1).",
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Kolh, P, Lambermont, B, Ghuysen, A, Tchana-Sato, V, Dogné, J-M, D'Orio, V, Gerard, P, Larbuisson, R & Limet, R 2004, 'Comparison of the effects of propofol and pentobarbital on left ventricular adaptation to an increased afterload', Journal of cardiovascular pharmacology, VOL. 44, Numéro 3, p. 294-301.

Comparison of the effects of propofol and pentobarbital on left ventricular adaptation to an increased afterload. / Kolh, Philippe; Lambermont, Bernard; Ghuysen, Alexandre; Tchana-Sato, Vincent; Dogné, Jean-Michel; D'Orio, Vincent; Gerard, Paul; Larbuisson, Robert; Limet, Raymond.

Dans: Journal of cardiovascular pharmacology, Vol 44, Numéro 3, 09.2004, p. 294-301.

Résultats de recherche: Contribution à un journal/une revueArticle

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T1 - Comparison of the effects of propofol and pentobarbital on left ventricular adaptation to an increased afterload

AU - Kolh, Philippe

AU - Lambermont, Bernard

AU - Ghuysen, Alexandre

AU - Tchana-Sato, Vincent

AU - Dogné, Jean-Michel

AU - D'Orio, Vincent

AU - Gerard, Paul

AU - Larbuisson, Robert

AU - Limet, Raymond

PY - 2004/9

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N2 - The purpose of this study was to compare the hemodynamic effects of pentobarbital and propofol and their effects on cardiovascular adaptation to an abrupt increase in left ventricular afterload. Experiments were performed in 12 open-chest pigs instrumented for measurement of aortic pressure and flow, and left ventricular pressure and volume. In one group (n = 6), anesthesia was obtained with sodium pentobarbital (3 mg x kg(-1) x h(-1)), and, in the second group B (n = 6), with propofol (10 mg x kg(-1) x h(-1)). Both groups received sufentanil (0.5 microg x kg(-1) x h(-1)) and pancuronium bromide (0.1 mg x kg(-1)). Left ventricular function was assessed by the slope of end-systolic pressure-volume relationship and stroke work. After baseline recordings, left ventricular afterload was increased by aortic banding. The cardiovascular adaptations triggered by the aortic banding, such as tachycardia, vasoconstriction, and augmentation of myocardial contractility were prevented with propofol, suggesting interference with the baroreflex. Increase in left ventricular afterload decreased mechanical efficiency, regardless of anesthetic agent. These results showed that pentobarbital at 3 mg x kg(-1) x h(-1) has less deleterious hemodynamic effects than propofol at 10 mg x kg(-1) x h(-1).

AB - The purpose of this study was to compare the hemodynamic effects of pentobarbital and propofol and their effects on cardiovascular adaptation to an abrupt increase in left ventricular afterload. Experiments were performed in 12 open-chest pigs instrumented for measurement of aortic pressure and flow, and left ventricular pressure and volume. In one group (n = 6), anesthesia was obtained with sodium pentobarbital (3 mg x kg(-1) x h(-1)), and, in the second group B (n = 6), with propofol (10 mg x kg(-1) x h(-1)). Both groups received sufentanil (0.5 microg x kg(-1) x h(-1)) and pancuronium bromide (0.1 mg x kg(-1)). Left ventricular function was assessed by the slope of end-systolic pressure-volume relationship and stroke work. After baseline recordings, left ventricular afterload was increased by aortic banding. The cardiovascular adaptations triggered by the aortic banding, such as tachycardia, vasoconstriction, and augmentation of myocardial contractility were prevented with propofol, suggesting interference with the baroreflex. Increase in left ventricular afterload decreased mechanical efficiency, regardless of anesthetic agent. These results showed that pentobarbital at 3 mg x kg(-1) x h(-1) has less deleterious hemodynamic effects than propofol at 10 mg x kg(-1) x h(-1).

KW - Adaptation, Physiological

KW - Animals

KW - Aorta

KW - Blood Pressure

KW - Cardiac Output

KW - Cardiac Volume

KW - Elasticity

KW - Female

KW - Heart Rate

KW - Infusions, Intravenous

KW - Male

KW - Pentobarbital

KW - Propofol

KW - Pulse

KW - Stroke Volume

KW - Swine

KW - Vascular Resistance

KW - Ventricular Function, Left

M3 - Article

C2 - 15475825

VL - 44

SP - 294

EP - 301

JO - Journal of cardiovascular pharmacology

JF - Journal of cardiovascular pharmacology

SN - 0160-2446

IS - 3

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