Comparison of the behavior of oxidosqualene cyclases from pig liver and yeast toward epoxy-squalene analogues possessing a Δ  Z or E C, C Double bond.

A. Krief; P. Pasau; L. Quéré

Comparison of the behavior of oxidosqualene cyclases from pig liver and yeast toward epoxy-squalene analogues possessing a Δ Z or E C, C Double bond.

A. Krief, P. Pasau, L. Quéré

Unite de recherche en chimie organique

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

2,3-Oxidosqualene analogues possessing a Δ double bond with the natural E-stereochemistry 1b-d are cyclised by pig liver sterol cyclase or "ultrasonically stimulated⌉ bakers' yeast (Saccharomyces cerevisiae) whereas their stereoisomers possessing a Δsu18-19 double bond with the unnatural Z-stereochemistry 1′ possess a different behaviour toward the same cyclases. They are still cyclised by pig liver sterol cyclase but are inert toward "ultrasonically stimulated" bakers' yeast. 2,3-Oxidosqualene analogues possessing a Δ double bond with the natural E-stereochemistry are cyclised by pig liver sterol cyclase or "ultrasonically stimulated" bakers' yeast (Saccharomyces cerevisiae) whereas their stereoisomers possessing a Δ double bond with the unnatural Z-stereochemistry possess a different behaviour toward the same cyclases. They are still cyclised by pig liver sterol cyclase but are inert toward "ultrasonically stimulated" bakers' yeast.

langue originale	Anglais
Pages (de - à)	365-368
Nombre de pages	4
journal	Bioorganic & Medicinal Chemistry Letters
Volume	1
Numéro de publication	7
Etat de la publication	Publié - 1 janv. 1991

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title = "Comparison of the behavior of oxidosqualene cyclases from pig liver and yeast toward epoxy-squalene analogues possessing a Δ Z or E C, C Double bond.",

abstract = "2,3-Oxidosqualene analogues possessing a Δ double bond with the natural E-stereochemistry 1b-d are cyclised by pig liver sterol cyclase or {"}ultrasonically stimulated⌉ bakers' yeast (Saccharomyces cerevisiae) whereas their stereoisomers possessing a Δsu18-19 double bond with the unnatural Z-stereochemistry 1′ possess a different behaviour toward the same cyclases. They are still cyclised by pig liver sterol cyclase but are inert toward {"}ultrasonically stimulated{"} bakers' yeast. 2,3-Oxidosqualene analogues possessing a Δ double bond with the natural E-stereochemistry are cyclised by pig liver sterol cyclase or {"}ultrasonically stimulated{"} bakers' yeast (Saccharomyces cerevisiae) whereas their stereoisomers possessing a Δ double bond with the unnatural Z-stereochemistry possess a different behaviour toward the same cyclases. They are still cyclised by pig liver sterol cyclase but are inert toward {"}ultrasonically stimulated{"} bakers' yeast.",

author = "A. Krief and P. Pasau and L. Qu{\'e}r{\'e}",

year = "1991",

month = jan,

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language = "English",

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pages = "365--368",

journal = "Bioorganic & Medicinal Chemistry Letters",

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Comparison of the behavior of oxidosqualene cyclases from pig liver and yeast toward epoxy-squalene analogues possessing a Δ Z or E C, C Double bond. / Krief, A.; Pasau, P.; Quéré, L.
Dans: Bioorganic & Medicinal Chemistry Letters, Vol 1, Numéro 7, 01.01.1991, p. 365-368.

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

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T1 - Comparison of the behavior of oxidosqualene cyclases from pig liver and yeast toward epoxy-squalene analogues possessing a Δ Z or E C, C Double bond.

AU - Krief, A.

AU - Pasau, P.

AU - Quéré, L.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - 2,3-Oxidosqualene analogues possessing a Δ double bond with the natural E-stereochemistry 1b-d are cyclised by pig liver sterol cyclase or "ultrasonically stimulated⌉ bakers' yeast (Saccharomyces cerevisiae) whereas their stereoisomers possessing a Δsu18-19 double bond with the unnatural Z-stereochemistry 1′ possess a different behaviour toward the same cyclases. They are still cyclised by pig liver sterol cyclase but are inert toward "ultrasonically stimulated" bakers' yeast. 2,3-Oxidosqualene analogues possessing a Δ double bond with the natural E-stereochemistry are cyclised by pig liver sterol cyclase or "ultrasonically stimulated" bakers' yeast (Saccharomyces cerevisiae) whereas their stereoisomers possessing a Δ double bond with the unnatural Z-stereochemistry possess a different behaviour toward the same cyclases. They are still cyclised by pig liver sterol cyclase but are inert toward "ultrasonically stimulated" bakers' yeast.

AB - 2,3-Oxidosqualene analogues possessing a Δ double bond with the natural E-stereochemistry 1b-d are cyclised by pig liver sterol cyclase or "ultrasonically stimulated⌉ bakers' yeast (Saccharomyces cerevisiae) whereas their stereoisomers possessing a Δsu18-19 double bond with the unnatural Z-stereochemistry 1′ possess a different behaviour toward the same cyclases. They are still cyclised by pig liver sterol cyclase but are inert toward "ultrasonically stimulated" bakers' yeast. 2,3-Oxidosqualene analogues possessing a Δ double bond with the natural E-stereochemistry are cyclised by pig liver sterol cyclase or "ultrasonically stimulated" bakers' yeast (Saccharomyces cerevisiae) whereas their stereoisomers possessing a Δ double bond with the unnatural Z-stereochemistry possess a different behaviour toward the same cyclases. They are still cyclised by pig liver sterol cyclase but are inert toward "ultrasonically stimulated" bakers' yeast.

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SN - 0960-894X

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JO - Bioorganic & Medicinal Chemistry Letters

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Comparison of the behavior of oxidosqualene cyclases from pig liver and yeast toward epoxy-squalene analogues possessing a Δ Z or E C, C Double bond.

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