Comparison between pulmonary resistance and Penh in anaesthetised rats with tracheal diameter reduction and after carbachol inhalation.

Nathalie Kirschvink, G. VINCKE, C. ONCLINCX, M. PECK, P. GUSTIN

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Résumé

Introduction: Single-chambered barometric whole-body plethysmography is frequently used as a noninvasive lung function test. However, the validity of the enhanced Pause (Penh), an index of airflow limitation, remains controversial. We compared Penh with pulmonary resistance (R(L)) to test whether Penh detects tracheal subobstruction and carbachol-induced airflow limitation in spontaneously breathing, anaesthetised rats. Methods: Fourteen male Sprague-Dawley rats underwent tracheal catheterisation, followed by measurements of R(L) and Penh. Six rats underwent tracheal subobstruction by the consecutive insertion into the lumen of the tracheal tube of two catheters of decreasing diameter. Eight rats received an inhaled saline challenge, followed by two noncumulative nebulizations of carbachol (1.25 mg/mL, 1 min). Results: In rats with tracheal calibre reductions, R(L) significantly increased at each reduction (0.218+/-0.052 vs. 0.417+/-0.058 vs. 0.820+/-0.258 cm H(2)O/mL s, p
langue originaleAnglais
Pages (de - à)123-128
Nombre de pages6
journalJournal Pharmacological and Toxicol Methods
Volume51
Etat de la publicationPublié - 2005

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