Combining piracetam and lithium salts: Ionic co-crystals and co-drugs?

Dario Braga; Fabrizia Grepioni; Lucia Maini; Davide Capucci; Saverio Nanna; Johan Wouters; Luc Aerts; Luc Quéré

doi:10.1039/c2cc33855f

Combining piracetam and lithium salts: Ionic co-crystals and co-drugs?

Dario Braga, Fabrizia Grepioni, Lucia Maini, Davide Capucci, Saverio Nanna, Johan Wouters, Luc Aerts, Luc Quéré

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.

langue originale	Anglais
Pages (de - à)	8219-8221
Nombre de pages	3
journal	Chemical Communications
Volume	48
Numéro de publication	66
Les DOIs	https://doi.org/10.1039/c2cc33855f
Etat de la publication	Publié - 25 août 2012

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10.1039/c2cc33855f

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Physico-chimie et caractérisation (PC2)
Johan Wouters (!!Manager) & Carmela Aprile (!!Manager)
Plateforme technologique Caracterisation physico-chimiques
Equipement/installations: Plateforme technolgique

CCDC 884811: Experimental Crystal Structure Determination
Aerts, L. (Contributeur), Braga, D. (Contributeur), Capucci, D. (Contributeur), Grepioni, F. (Contributeur), Maini, L. (Contributeur), Nanna, S. (Contributeur), Quere, L. (Contributeur) & Wouters, J. (Contributeur), Cambridge Crystallographic Data Centre, 1 janv. 2012
DOI: 10.5517/ccypq9m, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccypq9m&sid=DataCite
Ensemble de données
CCDC 884812: Experimental Crystal Structure Determination
Aerts, L. (Contributeur), Braga, D. (Contributeur), Capucci, D. (Contributeur), Grepioni, F. (Contributeur), Maini, L. (Contributeur), Nanna, S. (Contributeur), Quere, L. (Contributeur) & Wouters, J. (Contributeur), Cambridge Crystallographic Data Centre, 1 janv. 2012
DOI: 10.5517/ccypqbn, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccypqbn&sid=DataCite
Ensemble de données
CCDC 884810: Experimental Crystal Structure Determination
Aerts, L. (Contributeur), Braga, D. (Contributeur), Capucci, D. (Contributeur), Grepioni, F. (Contributeur), Maini, L. (Contributeur), Nanna, S. (Contributeur), Quere, L. (Contributeur) & Wouters, J. (Contributeur), Cambridge Crystallographic Data Centre, 1 janv. 2012
DOI: 10.5517/ccypq8l, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccypq8l&sid=DataCite
Ensemble de données

Contient cette citation

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title = "Combining piracetam and lithium salts: Ionic co-crystals and co-drugs?",

abstract = "Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.",

author = "Dario Braga and Fabrizia Grepioni and Lucia Maini and Davide Capucci and Saverio Nanna and Johan Wouters and Luc Aerts and Luc Qu{\'e}r{\'e}",

year = "2012",

month = aug,

day = "25",

doi = "10.1039/c2cc33855f",

language = "English",

volume = "48",

pages = "8219--8221",

journal = "Chemical Communications",

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T2 - Ionic co-crystals and co-drugs?

AU - Braga, Dario

AU - Grepioni, Fabrizia

AU - Maini, Lucia

AU - Capucci, Davide

AU - Nanna, Saverio

AU - Wouters, Johan

AU - Aerts, Luc

AU - Quéré, Luc

PY - 2012/8/25

Y1 - 2012/8/25

N2 - Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.

AB - Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.

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U2 - 10.1039/c2cc33855f

DO - 10.1039/c2cc33855f

M3 - Article

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AN - SCOPUS:84864205684

SN - 1359-7345

VL - 48

SP - 8219

EP - 8221

JO - Chemical Communications

JF - Chemical Communications

IS - 66

ER -

Combining piracetam and lithium salts: Ionic co-crystals and co-drugs?

Résumé

Accès au document

Autres fichiers et liens

Empreinte digitale

Équipement

Physico-chimie et caractérisation (PC2)

Ensembles de données

CCDC 884811: Experimental Crystal Structure Determination

CCDC 884812: Experimental Crystal Structure Determination

CCDC 884810: Experimental Crystal Structure Determination

Contient cette citation