Combining piracetam and lithium salts: Ionic co-crystals and co-drugs?

Dario Braga, Fabrizia Grepioni, Lucia Maini, Davide Capucci, Saverio Nanna, Johan Wouters, Luc Aerts, Luc Quéré

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs


Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.

langue originaleAnglais
Pages (de - à)8219-8221
Nombre de pages3
journalChemical Communications
Numéro de publication66
Les DOIs
Etat de la publicationPublié - 25 août 2012

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