TY - JOUR
T1 - Chiral Resolution of Mandelic Acid through Preferential Cocrystallization with Nefiracetam
AU - Buol, Xavier
AU - Caro Garrido, Camila
AU - Robeyns, Koen
AU - Tumanov, Nikolay
AU - Collard, Laurent
AU - Wouters, Johan
AU - Leyssens, Tom
N1 - Publisher Copyright:
©
PY - 2020/12/2
Y1 - 2020/12/2
N2 - In this paper, we identified a cocrystal conglomerate of mandelic acid using a drug compound as a coformer. We then developed a chiral resolution process based on preferential cocrystallization. Several versions of such a process were explored and optimized, leading to a successful resolution of mandelic acid, evidencing the efficiency of our system. Excellent enantiopurity (98-99%) was obtained with a process that can run for multiple cycles.
AB - In this paper, we identified a cocrystal conglomerate of mandelic acid using a drug compound as a coformer. We then developed a chiral resolution process based on preferential cocrystallization. Several versions of such a process were explored and optimized, leading to a successful resolution of mandelic acid, evidencing the efficiency of our system. Excellent enantiopurity (98-99%) was obtained with a process that can run for multiple cycles.
UR - http://www.scopus.com/inward/record.url?scp=85096582364&partnerID=8YFLogxK
U2 - 10.1021/acs.cgd.0c01236
DO - 10.1021/acs.cgd.0c01236
M3 - Article
AN - SCOPUS:85096582364
SN - 1528-7483
VL - 20
SP - 7979
EP - 7988
JO - Crystal Growth and Design
JF - Crystal Growth and Design
IS - 12
ER -