Caulobacter crescentus intrinsic dimorphism provides a prompt bimodal response to copper stress

Émeline Lawaree, Sébastien Gillet, Gwennaëlle Louis, Françoise Tilquin, Sophie Le Blastier, Pierre Cambier, Jean-Yves Matroule

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Résumé

Stress response to fluctuating environments often implies a time-consuming reprogramming of gene expression. In bacteria, the so-called bet hedging strategy, which promotes phenotypic stochasticity within a cell population, is the only fast stress response described so far 1. Here, we show that Caulobacter crescentus asymmetrical cell division allows an immediate bimodal response to a toxic metals-rich environment by allocating specific defence strategies to morphologically and functionally distinct siblings. In this context, a motile swarmer cell favours negative chemotaxis to flee from a copper source, whereas a sessile stalked sibling engages a ready-to-use PcoAB copper homeostasis system, providing evidence of a prompt stress response through intrinsic bacterial dimorphism.

langue originaleAnglais
Numéro d'article16098
journalNature Microbiology
Volume1
Numéro de publication9
Les DOIs
Etat de la publicationPublié - 4 juil. 2016

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