Capillary electrophoresis in the context of drug discovery

Elena Farcaş, Lionel Pochet, Jacques Crommen, Anne Catherine Servais, Marianne Fillet

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

Capillary Electrophoresis is a very efficient and resolutive separation technique used for many years in the analytical field. Despite all its assets, CE remains poorly used in drug discovery. This can be explained by the relatively low number of experienced CE practitioners, the maturity of HPLC in the pharmaceutical industry and some intrinsic limitations of the technique. The objective of this review is to focus our attention on recent developments of this technique in three different drug discovery areas: bioassays, drug-plasma interactions and drug metabolism studies. These developments were based on two important abilities of CE: the capacity to measure non-covalent interactions in solution and the ability to use a portion of the capillary as a reactor while the rest of the capillary is used for the separation of the product of the reaction.

langue originaleAnglais
Pages (de - à)195-212
Nombre de pages18
journalJournal of pharmaceutical and biomedical analysis
Volume144
Date de mise en ligne précoce2017
Les DOIs
Etat de la publicationPublié - 10 sept. 2017
Modification externeOui

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