Capillary electrophoresis in the context of drug discovery

Elena Farcaş, Lionel Pochet, Jacques Crommen, Anne Catherine Servais, Marianne Fillet

Résultats de recherche: Recherche - Revue par des pairsArticle

Résumé

Capillary Electrophoresis is a very efficient and resolutive separation technique used for many years in the analytical field. Despite all its assets, CE remains poorly used in drug discovery. This can be explained by the relatively low number of experienced CE practitioners, the maturity of HPLC in the pharmaceutical industry and some intrinsic limitations of the technique. The objective of this review is to focus our attention on recent developments of this technique in three different drug discovery areas: bioassays, drug-plasma interactions and drug metabolism studies. These developments were based on two important abilities of CE: the capacity to measure non-covalent interactions in solution and the ability to use a portion of the capillary as a reactor while the rest of the capillary is used for the separation of the product of the reaction.

langueAnglais
journalJournal of pharmaceutical and biomedical analysis
Les DOIs
étatE-pub ahead of print - 2017
Modification externeOui

Empreinte digitale

Capillary Electrophoresis
Drug Discovery
Capillary electrophoresis
Pharmaceutical Preparations
Drug Industry
Drug Interactions
Biological Assay
High Pressure Liquid Chromatography
Plasma interactions
Bioassay
Metabolism
Industry

mots-clés

    Citer ceci

    Farcaş, Elena ; Pochet, Lionel ; Crommen, Jacques ; Servais, Anne Catherine ; Fillet, Marianne. / Capillary electrophoresis in the context of drug discovery. Dans: Journal of pharmaceutical and biomedical analysis. 2017
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    Capillary electrophoresis in the context of drug discovery. / Farcaş, Elena; Pochet, Lionel; Crommen, Jacques; Servais, Anne Catherine; Fillet, Marianne.

    Dans: Journal of pharmaceutical and biomedical analysis, 2017.

    Résultats de recherche: Recherche - Revue par des pairsArticle

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    T1 - Capillary electrophoresis in the context of drug discovery

    AU - Farcaş,Elena

    AU - Pochet,Lionel

    AU - Crommen,Jacques

    AU - Servais,Anne Catherine

    AU - Fillet,Marianne

    N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

    PY - 2017

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    N2 - Capillary Electrophoresis is a very efficient and resolutive separation technique used for many years in the analytical field. Despite all its assets, CE remains poorly used in drug discovery. This can be explained by the relatively low number of experienced CE practitioners, the maturity of HPLC in the pharmaceutical industry and some intrinsic limitations of the technique. The objective of this review is to focus our attention on recent developments of this technique in three different drug discovery areas: bioassays, drug-plasma interactions and drug metabolism studies. These developments were based on two important abilities of CE: the capacity to measure non-covalent interactions in solution and the ability to use a portion of the capillary as a reactor while the rest of the capillary is used for the separation of the product of the reaction.

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