Calcium Carbonate Nanoplate Assemblies with Directed High-Energy Facets: Additive-Free Synthesis, High Drug Loading, and Sustainable Releasing

Jing Zhang, Yu Li, Hao Xie, Bao Lian Su, Bin Yao, Yixia Yin, Shipu Li, Fang Chen, Zhengyi Fu

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

Developing drug delivery systems (DDSs) with high drug-loading capacity and sustainable releasing is critical for long-term chemotherapeutic efficacy, and it still remains challenging. Herein, vaterite CaCO<inf>3</inf> nanoplate assemblies with exposed high-energy {001} facets have been synthesized via a novel, additive-free strategy. The product shows a high doxorubicin-loading capacity (65%); the best of all the CaCO<inf>3</inf>-based DDSs so far. Also, the product's sustainable releasing performance and its inhibition of the initial burst release, together, endow it with long-term drug efficacy. The work may shed light on exposing directed high-energy facets for rationally designing of a drug delivery system with long-term efficacy. (Graph Presented).

langue originaleAnglais
Pages (de - à)15686-15691
Nombre de pages6
journalACS Applied Materials and Interfaces
Volume7
Numéro de publication29
Les DOIs
étatPublié - 29 juil. 2015

Empreinte digitale

Calcium Carbonate
Calcium carbonate
Pharmaceutical Preparations
Doxorubicin
Drug Delivery Systems

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abstract = "Developing drug delivery systems (DDSs) with high drug-loading capacity and sustainable releasing is critical for long-term chemotherapeutic efficacy, and it still remains challenging. Herein, vaterite CaCO3 nanoplate assemblies with exposed high-energy {001} facets have been synthesized via a novel, additive-free strategy. The product shows a high doxorubicin-loading capacity (65{\%}); the best of all the CaCO3-based DDSs so far. Also, the product's sustainable releasing performance and its inhibition of the initial burst release, together, endow it with long-term drug efficacy. The work may shed light on exposing directed high-energy facets for rationally designing of a drug delivery system with long-term efficacy. (Graph Presented).",
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Calcium Carbonate Nanoplate Assemblies with Directed High-Energy Facets: Additive-Free Synthesis, High Drug Loading, and Sustainable Releasing. / Zhang, Jing; Li, Yu; Xie, Hao; Su, Bao Lian; Yao, Bin; Yin, Yixia; Li, Shipu; Chen, Fang; Fu, Zhengyi.

Dans: ACS Applied Materials and Interfaces, Vol 7, Numéro 29, 29.07.2015, p. 15686-15691.

Résultats de recherche: Contribution à un journal/une revueArticle

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AU - Zhang, Jing

AU - Li, Yu

AU - Xie, Hao

AU - Su, Bao Lian

AU - Yao, Bin

AU - Yin, Yixia

AU - Li, Shipu

AU - Chen, Fang

AU - Fu, Zhengyi

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KW - additive-free synthesis

KW - calcium carbonate

KW - drug delivery

KW - high-energy facet

KW - nanostructure

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