Résumé
Developing drug delivery systems (DDSs) with high drug-loading capacity and sustainable releasing is critical for long-term chemotherapeutic efficacy, and it still remains challenging. Herein, vaterite CaCO<inf>3</inf> nanoplate assemblies with exposed high-energy {001} facets have been synthesized via a novel, additive-free strategy. The product shows a high doxorubicin-loading capacity (65%); the best of all the CaCO<inf>3</inf>-based DDSs so far. Also, the product's sustainable releasing performance and its inhibition of the initial burst release, together, endow it with long-term drug efficacy. The work may shed light on exposing directed high-energy facets for rationally designing of a drug delivery system with long-term efficacy. (Graph Presented).
langue originale | Anglais |
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Pages (de - à) | 15686-15691 |
Nombre de pages | 6 |
journal | ACS Applied Materials and Interfaces |
Volume | 7 |
Numéro de publication | 29 |
Les DOIs | |
Etat de la publication | Publié - 29 juil. 2015 |
Empreinte digitale
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Physico-chimie et caractérisation (PC2)
Johan Wouters (!!Manager) & Carmela Aprile (!!Manager)
Plateforme technologique Caracterisation physico-chimiquesEquipement/installations: Plateforme technolgique