Calcitonin: Survey of new anatomy data to pathology and therapeutic aspects

Omar Faour, Jacques Gilloteaux

Résultats de recherche: Contribution à un journal/une revueArticle de revue

Résumé

Since the discovery of calcitonin (CT) reports have questioned the physiological role of human CT in regulating calcemia. This peptide is produced out of the CT/CGRP gene splicing along with other factors or hormones, including somatostatin by synonymously called parafollicular cells, C thyrocytes or C cells located in the thyroid glands. The C cells have recently been proven to originate out of the ultimobranchial anlage of the pharyngeal endoderm instead of the neural crest cells as indicated in all textbooks. Both blood and urine CT and procalcitonin (proCT) found in human and other mammals can also be secreted by cells located outside the thyroid glands. Taking account of dietetic calcium intake, CT assists in the homeostasis of bone mineral mass during growth, lactation, and pregnancy, hypo- and hyper gravity along with other paracrine thyroid secretions. Excess CT level in tissue fluids, needle aspirations and, now proCT, can diagnose sepsis, medullary thyroid or other carcinomas; caution to be taken with ectopic CT and gender-difference levels. Salmon CT as diurnal oral delivery seems, if proven not toxic, best suited to continue preventing or treating several defects, especially osteoporosis, orthopedic-related pains, perinatal or acute, fatal hypercalcemia. Contemplating old with recent physiological clinical results, human longitudinal morphologic and molecular data dealing with C cells and their paracrine interactions are few while only animal studies make us know much about CT. Human samples out of biopsies or cadavers should be further endeavored from development to aging to fully correlate normal with extreme or peculiar pathologies.

langueAnglais
Pages4-15
Nombre de pages12
journalTranslational Research in Anatomy
Volume6
Les DOIs
étatPublié - 1 mars 2017

Empreinte digitale

Calcitonin
Anatomy
Pathology
Therapeutics
Surveys and Questionnaires
Thyroid Gland
Hypercalcemia
salmon calcitonin
Endoderm
Dietetics
Textbooks
Neural Crest
Poisons
Gravitation
Somatostatin
Cadaver
Lactation
Osteoporosis
Needles
Orthopedics

mots-clés

    Citer ceci

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    abstract = "Since the discovery of calcitonin (CT) reports have questioned the physiological role of human CT in regulating calcemia. This peptide is produced out of the CT/CGRP gene splicing along with other factors or hormones, including somatostatin by synonymously called parafollicular cells, C thyrocytes or C cells located in the thyroid glands. The C cells have recently been proven to originate out of the ultimobranchial anlage of the pharyngeal endoderm instead of the neural crest cells as indicated in all textbooks. Both blood and urine CT and procalcitonin (proCT) found in human and other mammals can also be secreted by cells located outside the thyroid glands. Taking account of dietetic calcium intake, CT assists in the homeostasis of bone mineral mass during growth, lactation, and pregnancy, hypo- and hyper gravity along with other paracrine thyroid secretions. Excess CT level in tissue fluids, needle aspirations and, now proCT, can diagnose sepsis, medullary thyroid or other carcinomas; caution to be taken with ectopic CT and gender-difference levels. Salmon CT as diurnal oral delivery seems, if proven not toxic, best suited to continue preventing or treating several defects, especially osteoporosis, orthopedic-related pains, perinatal or acute, fatal hypercalcemia. Contemplating old with recent physiological clinical results, human longitudinal morphologic and molecular data dealing with C cells and their paracrine interactions are few while only animal studies make us know much about CT. Human samples out of biopsies or cadavers should be further endeavored from development to aging to fully correlate normal with extreme or peculiar pathologies.",
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    Calcitonin : Survey of new anatomy data to pathology and therapeutic aspects. / Faour, Omar; Gilloteaux, Jacques.

    Dans: Translational Research in Anatomy, Vol 6, 01.03.2017, p. 4-15.

    Résultats de recherche: Contribution à un journal/une revueArticle de revue

    TY - JOUR

    T1 - Calcitonin

    T2 - Translational Research in Anatomy

    AU - Faour,Omar

    AU - Gilloteaux,Jacques

    PY - 2017/3/1

    Y1 - 2017/3/1

    N2 - Since the discovery of calcitonin (CT) reports have questioned the physiological role of human CT in regulating calcemia. This peptide is produced out of the CT/CGRP gene splicing along with other factors or hormones, including somatostatin by synonymously called parafollicular cells, C thyrocytes or C cells located in the thyroid glands. The C cells have recently been proven to originate out of the ultimobranchial anlage of the pharyngeal endoderm instead of the neural crest cells as indicated in all textbooks. Both blood and urine CT and procalcitonin (proCT) found in human and other mammals can also be secreted by cells located outside the thyroid glands. Taking account of dietetic calcium intake, CT assists in the homeostasis of bone mineral mass during growth, lactation, and pregnancy, hypo- and hyper gravity along with other paracrine thyroid secretions. Excess CT level in tissue fluids, needle aspirations and, now proCT, can diagnose sepsis, medullary thyroid or other carcinomas; caution to be taken with ectopic CT and gender-difference levels. Salmon CT as diurnal oral delivery seems, if proven not toxic, best suited to continue preventing or treating several defects, especially osteoporosis, orthopedic-related pains, perinatal or acute, fatal hypercalcemia. Contemplating old with recent physiological clinical results, human longitudinal morphologic and molecular data dealing with C cells and their paracrine interactions are few while only animal studies make us know much about CT. Human samples out of biopsies or cadavers should be further endeavored from development to aging to fully correlate normal with extreme or peculiar pathologies.

    AB - Since the discovery of calcitonin (CT) reports have questioned the physiological role of human CT in regulating calcemia. This peptide is produced out of the CT/CGRP gene splicing along with other factors or hormones, including somatostatin by synonymously called parafollicular cells, C thyrocytes or C cells located in the thyroid glands. The C cells have recently been proven to originate out of the ultimobranchial anlage of the pharyngeal endoderm instead of the neural crest cells as indicated in all textbooks. Both blood and urine CT and procalcitonin (proCT) found in human and other mammals can also be secreted by cells located outside the thyroid glands. Taking account of dietetic calcium intake, CT assists in the homeostasis of bone mineral mass during growth, lactation, and pregnancy, hypo- and hyper gravity along with other paracrine thyroid secretions. Excess CT level in tissue fluids, needle aspirations and, now proCT, can diagnose sepsis, medullary thyroid or other carcinomas; caution to be taken with ectopic CT and gender-difference levels. Salmon CT as diurnal oral delivery seems, if proven not toxic, best suited to continue preventing or treating several defects, especially osteoporosis, orthopedic-related pains, perinatal or acute, fatal hypercalcemia. Contemplating old with recent physiological clinical results, human longitudinal morphologic and molecular data dealing with C cells and their paracrine interactions are few while only animal studies make us know much about CT. Human samples out of biopsies or cadavers should be further endeavored from development to aging to fully correlate normal with extreme or peculiar pathologies.

    KW - Calcemia

    KW - Calcitonin

    KW - Carcinoma

    KW - ECMO

    KW - Endoderm

    KW - Osteoporosis

    KW - Perinatal

    KW - Pro calcitonin

    KW - Salmon calcitonin

    UR - http://www.scopus.com/inward/record.url?scp=85012986129&partnerID=8YFLogxK

    U2 - 10.1016/j.tria.2017.01.001

    DO - 10.1016/j.tria.2017.01.001

    M3 - Review article

    VL - 6

    SP - 4

    EP - 15

    JO - Translational Research in Anatomy

    JF - Translational Research in Anatomy

    SN - 2214-854X

    ER -