Cadmium exposure exerts neurotoxic effects in peacock blennies Salaria pavo

Azza Naïja, Patrick Kestemont, Benoit Chénais, Zohra Haouas, Ronny Blust, Ahmed Noureddine Helal, Justine Marchand

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

Cadmium (Cd) is considered as an important factor involved in several neurological disturbances. The aim of this study was to assess the effects of Cd in the brain of peacock blennies Salaria pavo, a species used as a bioindicator of water pollution. A sublethal contamination of 2 mg CdCl2 L−1 was performed over periods of 1, 4, 10 and 15 days. Total Cd accumulation was measured in brains and displayed low concentrations throughout the experiment. Partial-length cDNA of different ATP-binding cassette transporters (abcb1, abcc1, abcc2, abcg2 proteins) and acetylcholinesterase (ache) were characterized. mRNA expressions profiles displayed an up-regulation of abcc2 mRNA after 4 days of Cd exposure only while abcg2 mRNA was down-regulated after 10 days only. For AChE, the mRNA transcription and the activity of the enzyme were followed and highlighted that Cd exerted an inhibitory effect on the nervous information transmission. At the histological level, fish exhibited pathological symptoms in the optic tectum and the cerebellum and results showed that the cerebellum was the most affected organ.

langueAnglais
Pages217-227
Nombre de pages11
journalEcotoxicology and Environmental Safety
Volume143
Les DOIs
étatPublié - 1 sept. 2017

Empreinte digitale

Cadmium
Messenger RNA
Cerebellum
Brain
Water Pollution
ATP-Binding Cassette Transporters
Water pollution
Superior Colliculi
Adenosinetriphosphate
Biomarkers
Transcription
Acetylcholinesterase
Fish
Optics
Fishes
Contamination
Up-Regulation
Enzymes
Complementary DNA
Proteins

mots-clés

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    Naïja, A., Kestemont, P., Chénais, B., Haouas, Z., Blust, R., Helal, A. N., & Marchand, J. (2017). Cadmium exposure exerts neurotoxic effects in peacock blennies Salaria pavo. Ecotoxicology and Environmental Safety, 143, 217-227. DOI: 10.1016/j.ecoenv.2017.05.041
    Naïja, Azza ; Kestemont, Patrick ; Chénais, Benoit ; Haouas, Zohra ; Blust, Ronny ; Helal, Ahmed Noureddine ; Marchand, Justine. / Cadmium exposure exerts neurotoxic effects in peacock blennies Salaria pavo. Dans: Ecotoxicology and Environmental Safety. 2017 ; Vol 143. p. 217-227
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    abstract = "Cadmium (Cd) is considered as an important factor involved in several neurological disturbances. The aim of this study was to assess the effects of Cd in the brain of peacock blennies Salaria pavo, a species used as a bioindicator of water pollution. A sublethal contamination of 2 mg CdCl2 L−1 was performed over periods of 1, 4, 10 and 15 days. Total Cd accumulation was measured in brains and displayed low concentrations throughout the experiment. Partial-length cDNA of different ATP-binding cassette transporters (abcb1, abcc1, abcc2, abcg2 proteins) and acetylcholinesterase (ache) were characterized. mRNA expressions profiles displayed an up-regulation of abcc2 mRNA after 4 days of Cd exposure only while abcg2 mRNA was down-regulated after 10 days only. For AChE, the mRNA transcription and the activity of the enzyme were followed and highlighted that Cd exerted an inhibitory effect on the nervous information transmission. At the histological level, fish exhibited pathological symptoms in the optic tectum and the cerebellum and results showed that the cerebellum was the most affected organ.",
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    Naïja, A, Kestemont, P, Chénais, B, Haouas, Z, Blust, R, Helal, AN & Marchand, J 2017, 'Cadmium exposure exerts neurotoxic effects in peacock blennies Salaria pavo' Ecotoxicology and Environmental Safety, VOL. 143, p. 217-227. DOI: 10.1016/j.ecoenv.2017.05.041

    Cadmium exposure exerts neurotoxic effects in peacock blennies Salaria pavo. / Naïja, Azza; Kestemont, Patrick; Chénais, Benoit; Haouas, Zohra; Blust, Ronny; Helal, Ahmed Noureddine; Marchand, Justine.

    Dans: Ecotoxicology and Environmental Safety, Vol 143, 01.09.2017, p. 217-227.

    Résultats de recherche: Contribution à un journal/une revueArticle

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    Naïja A, Kestemont P, Chénais B, Haouas Z, Blust R, Helal AN et al. Cadmium exposure exerts neurotoxic effects in peacock blennies Salaria pavo. Ecotoxicology and Environmental Safety. 2017 sept. 1;143:217-227. Disponible �, DOI: 10.1016/j.ecoenv.2017.05.041