Biotechnological promises of Fe-filled CNTs for cell shepherding and magnetic fluid hyperthermia applications

Florent Pineux, Riccardo Marega, Antoine Stopin, Alessandro La Torre, Yann Garcia, Eamonn Devlin, Carine Michiels, Andrei N. Khlobystov, Davide Bonifazi

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Fe-filled carbon nanotubes (Fe@CNTs) recently emerged as an effective class of hybrid nanoparticles for biotechnological applications, such as magnetic cell sorting and magnetic fluid hyperthermia. Aiming at studying the effects of both the Fe loading and the magnetocrystalline characteristics in these applications, we describe herein the preparation of Fe@CNTs containing different Fe phases that, upon functionalization with the antibody Cetuximab (Ctxb), allow the targeting of cancer cells. Our experimental findings reveal that an optimal Ctxb/Fe weight ratio of 1.2 is needed for efficient magnetic cell shepherding, whereas enhanced MFH-induced mortality (70 vs. 15%) can be reached with hybrids enriched in the coercive Fe3C phase. These results suggest that a synergistic effect between the Ab loading and the Fe distribution in each nanotube exists, for which the maximum shepherding and hyperthermia effects are observed when higher densities of Fe@CNTs featuring the more coercive phase are interfaced with the cells.

langue originaleAnglais
Pages (de - à)20474-20488
Nombre de pages15
Numéro de publication48
Les DOIs
Etat de la publicationPublié - 2015

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