TY - JOUR
T1 - Associations between Specific Redox Biomarkers and Age in a Large European Cohort
T2 - The MARK-AGE Project
AU - Weber, Daniela
AU - Stuetz, Wolfgang
AU - Toussaint, Olivier
AU - Debacq-Chainiaux, Florence
AU - Dollé, Martijn
AU - Jansen, Eugène
AU - Gonos, Efstathios S.
AU - Franceschi, Claudio
AU - Sikora, Ewa
AU - Hervonen, Antti
AU - Breusing, Nicole
AU - Sindlinger, Thilo
AU - Moreno-Villanueva, María
AU - Bürkle, Alexander
AU - Grune, Tilman
N1 - Publisher Copyright:
© 2017 Daniela Weber et al.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2017
Y1 - 2017
N2 - Oxidative stress and antioxidants play a role in age-related diseases and in the aging process. We here present data on protein carbonyls, 3-nitrotyrosine, malondialdehyde, and cellular and plasma antioxidants (glutathione, cysteine, ascorbic acid, uric acid, α-tocopherol, and lycopene) and their relation with age in the European multicenter study MARK-AGE. To avoid confounding, only data from countries which recruited subjects from all three study groups (five of eight centers) and only participants aged ≥55 years were selected resulting in data from 1559 participants. These included subjects from (1) the general population, (2) members from long-living families, and (3) their spouses. In addition, 683 middle-aged reference participants (35–54 years) served as a control. After adjustment for age, BMI, smoking status, gender, and country, there were differences in protein carbonyls, malondialdehyde, 3-nitrotyrosine, α-tocopherol, cysteine, and glutathione between the 3 study groups. Protein carbonyls and 3-nitrotyrosine as well as cysteine, uric acid, and lycopene were identified as independent biomarkers with the highest correlation with age. Interestingly, from all antioxidants measured, only lycopene was lower in all aged groups and from the oxidative stress biomarkers, only 3-nitrotyrosine was increased in the descendants from long-living families compared to the middle-aged control group. We conclude that both lifestyle and genetics may be important contributors to redox biomarkers in an aging population.
AB - Oxidative stress and antioxidants play a role in age-related diseases and in the aging process. We here present data on protein carbonyls, 3-nitrotyrosine, malondialdehyde, and cellular and plasma antioxidants (glutathione, cysteine, ascorbic acid, uric acid, α-tocopherol, and lycopene) and their relation with age in the European multicenter study MARK-AGE. To avoid confounding, only data from countries which recruited subjects from all three study groups (five of eight centers) and only participants aged ≥55 years were selected resulting in data from 1559 participants. These included subjects from (1) the general population, (2) members from long-living families, and (3) their spouses. In addition, 683 middle-aged reference participants (35–54 years) served as a control. After adjustment for age, BMI, smoking status, gender, and country, there were differences in protein carbonyls, malondialdehyde, 3-nitrotyrosine, α-tocopherol, cysteine, and glutathione between the 3 study groups. Protein carbonyls and 3-nitrotyrosine as well as cysteine, uric acid, and lycopene were identified as independent biomarkers with the highest correlation with age. Interestingly, from all antioxidants measured, only lycopene was lower in all aged groups and from the oxidative stress biomarkers, only 3-nitrotyrosine was increased in the descendants from long-living families compared to the middle-aged control group. We conclude that both lifestyle and genetics may be important contributors to redox biomarkers in an aging population.
KW - Adult
KW - Antioxidants/metabolism
KW - Ascorbic Acid/blood
KW - Biomarkers/blood
KW - Carotenoids/blood
KW - Female
KW - Glutathione/blood
KW - Humans
KW - Lipid Peroxidation/physiology
KW - Lycopene
KW - Male
KW - Malondialdehyde/blood
KW - Middle Aged
KW - Oxidation-Reduction
KW - Oxidative Stress/physiology
KW - Tyrosine/analogs & derivatives
KW - Uric Acid/blood
KW - alpha-Tocopherol/blood
UR - http://www.scopus.com/inward/record.url?scp=85027183502&partnerID=8YFLogxK
U2 - 10.1155/2017/1401452
DO - 10.1155/2017/1401452
M3 - Article
C2 - 28804532
SN - 1942-0900
VL - 2017
SP - 1401452
JO - Oxidative Medicine and Cellular Longevity
JF - Oxidative Medicine and Cellular Longevity
M1 - 1401452
ER -