Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project

Daniela Weber, Wolfgang Stuetz, Olivier Toussaint, Florence Debacq-Chainiaux, Martijn Dollé, Eugène Jansen, Efstathios S. Gonos, Claudio Franceschi, Ewa Sikora, Antti Hervonen, Nicole Breusing, Thilo Sindlinger, María Moreno-Villanueva, Alexander Bürkle, Tilman Grune

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

Oxidative stress and antioxidants play a role in age-related diseases and in the aging process. We here present data on protein carbonyls, 3-nitrotyrosine, malondialdehyde, and cellular and plasma antioxidants (glutathione, cysteine, ascorbic acid, uric acid, α-tocopherol, and lycopene) and their relation with age in the European multicenter study MARK-AGE. To avoid confounding, only data from countries which recruited subjects from all three study groups (five of eight centers) and only participants aged ≥55 years were selected resulting in data from 1559 participants. These included subjects from (1) the general population, (2) members from long-living families, and (3) their spouses. In addition, 683 middle-aged reference participants (35–54 years) served as a control. After adjustment for age, BMI, smoking status, gender, and country, there were differences in protein carbonyls, malondialdehyde, 3-nitrotyrosine, α-tocopherol, cysteine, and glutathione between the 3 study groups. Protein carbonyls and 3-nitrotyrosine as well as cysteine, uric acid, and lycopene were identified as independent biomarkers with the highest correlation with age. Interestingly, from all antioxidants measured, only lycopene was lower in all aged groups and from the oxidative stress biomarkers, only 3-nitrotyrosine was increased in the descendants from long-living families compared to the middle-aged control group. We conclude that both lifestyle and genetics may be important contributors to redox biomarkers in an aging population.
langue originaleAnglais
Numéro d'article1401452
journalOxidative Medicine and Cellular Longevity
Volume2017
Les DOIs
étatPublié - 2017

Empreinte digitale

Biomarkers
Oxidation-Reduction
Cysteine
Oxidative stress
Tocopherols
Antioxidants
Uric Acid
Malondialdehyde
Glutathione
Oxidative Stress
Aging of materials
Proteins
Spouses
Population
Ascorbic Acid
Multicenter Studies
Life Style
Smoking
Plasmas
Control Groups

Citer ceci

Weber, Daniela ; Stuetz, Wolfgang ; Toussaint, Olivier ; Debacq-Chainiaux, Florence ; Dollé, Martijn ; Jansen, Eugène ; Gonos, Efstathios S. ; Franceschi, Claudio ; Sikora, Ewa ; Hervonen, Antti ; Breusing, Nicole ; Sindlinger, Thilo ; Moreno-Villanueva, María ; Bürkle, Alexander ; Grune, Tilman. / Associations between Specific Redox Biomarkers and Age in a Large European Cohort : The MARK-AGE Project. Dans: Oxidative Medicine and Cellular Longevity. 2017 ; Vol 2017.
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title = "Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project",
abstract = "Oxidative stress and antioxidants play a role in age-related diseases and in the aging process. We here present data on protein carbonyls, 3-nitrotyrosine, malondialdehyde, and cellular and plasma antioxidants (glutathione, cysteine, ascorbic acid, uric acid, α-tocopherol, and lycopene) and their relation with age in the European multicenter study MARK-AGE. To avoid confounding, only data from countries which recruited subjects from all three study groups (five of eight centers) and only participants aged ≥55 years were selected resulting in data from 1559 participants. These included subjects from (1) the general population, (2) members from long-living families, and (3) their spouses. In addition, 683 middle-aged reference participants (35–54 years) served as a control. After adjustment for age, BMI, smoking status, gender, and country, there were differences in protein carbonyls, malondialdehyde, 3-nitrotyrosine, α-tocopherol, cysteine, and glutathione between the 3 study groups. Protein carbonyls and 3-nitrotyrosine as well as cysteine, uric acid, and lycopene were identified as independent biomarkers with the highest correlation with age. Interestingly, from all antioxidants measured, only lycopene was lower in all aged groups and from the oxidative stress biomarkers, only 3-nitrotyrosine was increased in the descendants from long-living families compared to the middle-aged control group. We conclude that both lifestyle and genetics may be important contributors to redox biomarkers in an aging population.",
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author = "Daniela Weber and Wolfgang Stuetz and Olivier Toussaint and Florence Debacq-Chainiaux and Martijn Doll{\'e} and Eug{\`e}ne Jansen and Gonos, {Efstathios S.} and Claudio Franceschi and Ewa Sikora and Antti Hervonen and Nicole Breusing and Thilo Sindlinger and Mar{\'i}a Moreno-Villanueva and Alexander B{\"u}rkle and Tilman Grune",
year = "2017",
doi = "10.1155/2017/1401452",
language = "English",
volume = "2017",
journal = "Oxidative Medicine and Cellular Longevity",
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Weber, D, Stuetz, W, Toussaint, O, Debacq-Chainiaux, F, Dollé, M, Jansen, E, Gonos, ES, Franceschi, C, Sikora, E, Hervonen, A, Breusing, N, Sindlinger, T, Moreno-Villanueva, M, Bürkle, A & Grune, T 2017, 'Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project', Oxidative Medicine and Cellular Longevity, VOL. 2017, 1401452. https://doi.org/10.1155/2017/1401452

Associations between Specific Redox Biomarkers and Age in a Large European Cohort : The MARK-AGE Project. / Weber, Daniela; Stuetz, Wolfgang; Toussaint, Olivier; Debacq-Chainiaux, Florence; Dollé, Martijn; Jansen, Eugène; Gonos, Efstathios S.; Franceschi, Claudio; Sikora, Ewa; Hervonen, Antti; Breusing, Nicole; Sindlinger, Thilo; Moreno-Villanueva, María; Bürkle, Alexander; Grune, Tilman.

Dans: Oxidative Medicine and Cellular Longevity, Vol 2017, 1401452, 2017.

Résultats de recherche: Contribution à un journal/une revueArticle

TY - JOUR

T1 - Associations between Specific Redox Biomarkers and Age in a Large European Cohort

T2 - The MARK-AGE Project

AU - Weber, Daniela

AU - Stuetz, Wolfgang

AU - Toussaint, Olivier

AU - Debacq-Chainiaux, Florence

AU - Dollé, Martijn

AU - Jansen, Eugène

AU - Gonos, Efstathios S.

AU - Franceschi, Claudio

AU - Sikora, Ewa

AU - Hervonen, Antti

AU - Breusing, Nicole

AU - Sindlinger, Thilo

AU - Moreno-Villanueva, María

AU - Bürkle, Alexander

AU - Grune, Tilman

PY - 2017

Y1 - 2017

N2 - Oxidative stress and antioxidants play a role in age-related diseases and in the aging process. We here present data on protein carbonyls, 3-nitrotyrosine, malondialdehyde, and cellular and plasma antioxidants (glutathione, cysteine, ascorbic acid, uric acid, α-tocopherol, and lycopene) and their relation with age in the European multicenter study MARK-AGE. To avoid confounding, only data from countries which recruited subjects from all three study groups (five of eight centers) and only participants aged ≥55 years were selected resulting in data from 1559 participants. These included subjects from (1) the general population, (2) members from long-living families, and (3) their spouses. In addition, 683 middle-aged reference participants (35–54 years) served as a control. After adjustment for age, BMI, smoking status, gender, and country, there were differences in protein carbonyls, malondialdehyde, 3-nitrotyrosine, α-tocopherol, cysteine, and glutathione between the 3 study groups. Protein carbonyls and 3-nitrotyrosine as well as cysteine, uric acid, and lycopene were identified as independent biomarkers with the highest correlation with age. Interestingly, from all antioxidants measured, only lycopene was lower in all aged groups and from the oxidative stress biomarkers, only 3-nitrotyrosine was increased in the descendants from long-living families compared to the middle-aged control group. We conclude that both lifestyle and genetics may be important contributors to redox biomarkers in an aging population.

AB - Oxidative stress and antioxidants play a role in age-related diseases and in the aging process. We here present data on protein carbonyls, 3-nitrotyrosine, malondialdehyde, and cellular and plasma antioxidants (glutathione, cysteine, ascorbic acid, uric acid, α-tocopherol, and lycopene) and their relation with age in the European multicenter study MARK-AGE. To avoid confounding, only data from countries which recruited subjects from all three study groups (five of eight centers) and only participants aged ≥55 years were selected resulting in data from 1559 participants. These included subjects from (1) the general population, (2) members from long-living families, and (3) their spouses. In addition, 683 middle-aged reference participants (35–54 years) served as a control. After adjustment for age, BMI, smoking status, gender, and country, there were differences in protein carbonyls, malondialdehyde, 3-nitrotyrosine, α-tocopherol, cysteine, and glutathione between the 3 study groups. Protein carbonyls and 3-nitrotyrosine as well as cysteine, uric acid, and lycopene were identified as independent biomarkers with the highest correlation with age. Interestingly, from all antioxidants measured, only lycopene was lower in all aged groups and from the oxidative stress biomarkers, only 3-nitrotyrosine was increased in the descendants from long-living families compared to the middle-aged control group. We conclude that both lifestyle and genetics may be important contributors to redox biomarkers in an aging population.

KW - Adult

KW - Antioxidants/metabolism

KW - Ascorbic Acid/blood

KW - Biomarkers/blood

KW - Carotenoids/blood

KW - Female

KW - Glutathione/blood

KW - Humans

KW - Lipid Peroxidation/physiology

KW - Lycopene

KW - Male

KW - Malondialdehyde/blood

KW - Middle Aged

KW - Oxidation-Reduction

KW - Oxidative Stress/physiology

KW - Tyrosine/analogs & derivatives

KW - Uric Acid/blood

KW - alpha-Tocopherol/blood

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U2 - 10.1155/2017/1401452

DO - 10.1155/2017/1401452

M3 - Article

VL - 2017

JO - Oxidative Medicine and Cellular Longevity

JF - Oxidative Medicine and Cellular Longevity

SN - 1942-0900

M1 - 1401452

ER -