Anticodon wobble uridine modification by Elongator at the crossroad of cell signaling, differentiation and diseases

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

28 Téléchargements (Pure)

Résumé

First identified 20 years ago as an RNA polymerase II-associated putative histone acetyltransferase, the conserved Elongator complex has since been recognized as the central player of a complex, regulated, and biologically relevant epitranscriptomic pathway targeting the wobble uridine of some tRNAs. Numerous studies have contributed to three emerging concepts resulting from anticodon modification by Elongator: the codon-specific control of translation, the ability of reprogramming translation in various physiological or pathological contexts, and the maintenance of proteome integrity by counteracting protein aggregation. These three aspects of tRNA modification by Elongator constitute a new layer of regulation that fundamentally contributes to gene expression and are now recognized as being critically involved in various human diseases.
langue originaleAnglais
Numéro d'article7
Nombre de pages15
journalEpigenomes
Volume4
Numéro de publication2
Les DOIs
Etat de la publicationPublié - 12 mai 2020

Empreinte digitale

Examiner les sujets de recherche de « Anticodon wobble uridine modification by Elongator at the crossroad of cell signaling, differentiation and diseases ». Ensemble, ils forment une empreinte digitale unique.

Contient cette citation