An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature

Inès Jadot, Anne-Emilie Decleves, Joëlle Nortier, Nathalie Caron

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

111 Téléchargements (Pure)

Résumé

The term “aristolochic acid nephropathy” (AAN) is used to include any form of toxic interstitial nephropathy that is caused either by ingestion of plants containing aristolochic acids (AA) as part of traditional phytotherapies (formerly known as “Chinese herbs nephropathy”), or by the environmental contaminants in food (Balkan endemic nephropathy). It is frequently associated with urothelial malignancies. Although products containing AA have been banned in most of countries, AAN cases remain regularly reported all over the world. Moreover, AAN incidence is probably highly underestimated given the presence of AA in traditional herbal remedies worldwide and the weak awareness of the disease. During these two past decades, animal models for AAN have been developed to investigate underlying molecular and cellular mechanisms involved in AAN pathogenesis. Indeed, a more-in-depth understanding of these processes is essential to develop therapeutic strategies aimed to reduce the global and underestimated burden of this disease. In this regard, our purpose was to build a broad overview of what is currently known about AAN. To achieve this goal, we aimed to summarize the latest data available about underlying pathophysiological mechanisms leading to AAN development with a particular emphasis on the imbalance between vasoactive factors as well as a focus on the vascular events often not considered in AAN.
langue originaleAnglais
Numéro d'article297
journalInternational Journal of Molecular Sciences
Volume18
Numéro de publication2
Les DOIs
Etat de la publicationPublié - 29 janv. 2017

mots-clés

  • nephrotoxicity

Empreinte digitale Examiner les sujets de recherche de « An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature ». Ensemble, ils forment une empreinte digitale unique.

Contient cette citation