TY - JOUR
T1 - An Integrated View of Aristolochic Acid Nephropathy
T2 - Update of the Literature
AU - Jadot, Inès
AU - Decleves, Anne-Emilie
AU - Nortier, Joëlle
AU - Caron, Nathalie
N1 - Publisher Copyright:
© 2017 by the authors; licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2017/1/29
Y1 - 2017/1/29
N2 - The term “aristolochic acid nephropathy” (AAN) is used to include any form of toxic interstitial nephropathy that is caused either by ingestion of plants containing aristolochic acids (AA) as part of traditional phytotherapies (formerly known as “Chinese herbs nephropathy”), or by the environmental contaminants in food (Balkan endemic nephropathy). It is frequently associated with urothelial malignancies. Although products containing AA have been banned in most of countries, AAN cases remain regularly reported all over the world. Moreover, AAN incidence is probably highly underestimated given the presence of AA in traditional herbal remedies worldwide and the weak awareness of the disease. During these two past decades, animal models for AAN have been developed to investigate underlying molecular and cellular mechanisms involved in AAN pathogenesis. Indeed, a more-in-depth understanding of these processes is essential to develop therapeutic strategies aimed to reduce the global and underestimated burden of this disease. In this regard, our purpose was to build a broad overview of what is currently known about AAN. To achieve this goal, we aimed to summarize the latest data available about underlying pathophysiological mechanisms leading to AAN development with a particular emphasis on the imbalance between vasoactive factors as well as a focus on the vascular events often not considered in AAN.
AB - The term “aristolochic acid nephropathy” (AAN) is used to include any form of toxic interstitial nephropathy that is caused either by ingestion of plants containing aristolochic acids (AA) as part of traditional phytotherapies (formerly known as “Chinese herbs nephropathy”), or by the environmental contaminants in food (Balkan endemic nephropathy). It is frequently associated with urothelial malignancies. Although products containing AA have been banned in most of countries, AAN cases remain regularly reported all over the world. Moreover, AAN incidence is probably highly underestimated given the presence of AA in traditional herbal remedies worldwide and the weak awareness of the disease. During these two past decades, animal models for AAN have been developed to investigate underlying molecular and cellular mechanisms involved in AAN pathogenesis. Indeed, a more-in-depth understanding of these processes is essential to develop therapeutic strategies aimed to reduce the global and underestimated burden of this disease. In this regard, our purpose was to build a broad overview of what is currently known about AAN. To achieve this goal, we aimed to summarize the latest data available about underlying pathophysiological mechanisms leading to AAN development with a particular emphasis on the imbalance between vasoactive factors as well as a focus on the vascular events often not considered in AAN.
KW - nephrotoxicity
KW - Aristolochic acids
KW - Balkan endemic nephropathy
KW - Herbal remedies
KW - Renal interstitial fibrosis
KW - Urothelial carcinoma
KW - Cell Transformation, Neoplastic/chemically induced
KW - Kidney Neoplasms/etiology
KW - Aristolochic Acids/adverse effects
KW - Oxidative Stress
KW - Humans
KW - Nephritis, Interstitial/diagnosis
KW - Drugs, Chinese Herbal/adverse effects
KW - Balkan Nephropathy/diagnosis
KW - Animals
KW - Biopsy
KW - Fibrosis
UR - http://www.scopus.com/inward/record.url?scp=85011085105&partnerID=8YFLogxK
U2 - 10.3390/ijms18020297
DO - 10.3390/ijms18020297
M3 - Article
SN - 1661-6596
VL - 18
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 2
M1 - 297
ER -