Age-related morphometric changes of the tidemark in the ovine stifle

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Résumé

Though the ovine stifle is commonly used to study osteoarthritis, there is limited information about the age-related morphometric changes of the tidemark. The objective of this study was to document the number of tidemarks in the stifle of research sheep without clinical signs of osteoarthritis and of various ages (n = 80). Articular cartilage of the medial and lateral tibial condyles and of the medial and lateral femoral condyles was assessed by histology: (1) to count the number of tidemark; and (2) to assess the OARSI (OsteoArthritis Research Society International) score for structural changes of cartilage. The number of tidemarks varied between anatomical regions respectively from 4.2 in the medial femoral condyle to 5.0 in the lateral tibial condyle. The axial part showed a significant higher number of tidemarks than the abaxial part, for all regions except the medial tibial condyle. While the tidemark count strongly correlated to age (Spearman Correlation coefficient=0.70; 95% confidence interval 0.67 to 0.73; P<0.0001), the OARSI score was weakly correlated to age in our cohort of sheep (Spearman Correlation coefficient=0.25; 95% confidence interval 0.19 to 0.30; P<0.0001). Interestingly, no tidemark was seen in the three animals aged 6 months. Our data indicate that the number of tidemarks increases with age and vary with anatomical region. The regional variation also revealed a higher number of tidemarks in the tibia than in the femur. This could be attributed to the local variation in cartilage response to strain and to the difference in chondrocyte biology and density.
langue originaleAnglais
Nombre de pages30
journalAnatomia, Histologia, Embryologia
Les DOIs
étatAccepté/sous presse - 2019

Empreinte digitale

Stifle
osteoarthritis
Sheep
Osteoarthritis
sheep
Bone and Bones
cartilage
thighs
Thigh
Cartilage
confidence interval
Research
Confidence Intervals
chondrocytes
Articular Cartilage
Chondrocytes
tibia
Tibia
femur
Femur

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    @article{2e2e33fee7aa4a16abd8b25769595115,
    title = "Age-related morphometric changes of the tidemark in the ovine stifle",
    abstract = "Though the ovine stifle is commonly used to study osteoarthritis, there is limited information about the age-related morphometric changes of the tidemark. The objective of this study was to document the number of tidemarks in the stifle of research sheep without clinical signs of osteoarthritis and of various ages (n = 80). Articular cartilage of the medial and lateral tibial condyles and of the medial and lateral femoral condyles was assessed by histology: (1) to count the number of tidemark; and (2) to assess the OARSI (OsteoArthritis Research Society International) score for structural changes of cartilage. The number of tidemarks varied between anatomical regions respectively from 4.2 in the medial femoral condyle to 5.0 in the lateral tibial condyle. The axial part showed a significant higher number of tidemarks than the abaxial part, for all regions except the medial tibial condyle. While the tidemark count strongly correlated to age (Spearman Correlation coefficient=0.70; 95{\%} confidence interval 0.67 to 0.73; P<0.0001), the OARSI score was weakly correlated to age in our cohort of sheep (Spearman Correlation coefficient=0.25; 95{\%} confidence interval 0.19 to 0.30; P<0.0001). Interestingly, no tidemark was seen in the three animals aged 6 months. Our data indicate that the number of tidemarks increases with age and vary with anatomical region. The regional variation also revealed a higher number of tidemarks in the tibia than in the femur. This could be attributed to the local variation in cartilage response to strain and to the difference in chondrocyte biology and density.",
    keywords = "sheep, cartilage, sifle, osteoarthritiss, ageing",
    author = "Fanny Hontoir and Romain Pirson and Vincent Simon and Clegg, {Peter D.} and Jean-Fran{\cc}ois Nisolle and Nathalie Kirschvink and Jean-Michel Vandeweerd",
    year = "2019",
    doi = "DOI:10.1111/ahe.12449",
    language = "English",
    journal = "Anatomia, Histologia, Embryologia",
    issn = "0340-2096",
    publisher = "Wiley-Blackwell",

    }

    TY - JOUR

    T1 - Age-related morphometric changes of the tidemark in the ovine stifle

    AU - Hontoir, Fanny

    AU - Pirson, Romain

    AU - Simon, Vincent

    AU - Clegg, Peter D.

    AU - Nisolle, Jean-François

    AU - Kirschvink, Nathalie

    AU - Vandeweerd, Jean-Michel

    PY - 2019

    Y1 - 2019

    N2 - Though the ovine stifle is commonly used to study osteoarthritis, there is limited information about the age-related morphometric changes of the tidemark. The objective of this study was to document the number of tidemarks in the stifle of research sheep without clinical signs of osteoarthritis and of various ages (n = 80). Articular cartilage of the medial and lateral tibial condyles and of the medial and lateral femoral condyles was assessed by histology: (1) to count the number of tidemark; and (2) to assess the OARSI (OsteoArthritis Research Society International) score for structural changes of cartilage. The number of tidemarks varied between anatomical regions respectively from 4.2 in the medial femoral condyle to 5.0 in the lateral tibial condyle. The axial part showed a significant higher number of tidemarks than the abaxial part, for all regions except the medial tibial condyle. While the tidemark count strongly correlated to age (Spearman Correlation coefficient=0.70; 95% confidence interval 0.67 to 0.73; P<0.0001), the OARSI score was weakly correlated to age in our cohort of sheep (Spearman Correlation coefficient=0.25; 95% confidence interval 0.19 to 0.30; P<0.0001). Interestingly, no tidemark was seen in the three animals aged 6 months. Our data indicate that the number of tidemarks increases with age and vary with anatomical region. The regional variation also revealed a higher number of tidemarks in the tibia than in the femur. This could be attributed to the local variation in cartilage response to strain and to the difference in chondrocyte biology and density.

    AB - Though the ovine stifle is commonly used to study osteoarthritis, there is limited information about the age-related morphometric changes of the tidemark. The objective of this study was to document the number of tidemarks in the stifle of research sheep without clinical signs of osteoarthritis and of various ages (n = 80). Articular cartilage of the medial and lateral tibial condyles and of the medial and lateral femoral condyles was assessed by histology: (1) to count the number of tidemark; and (2) to assess the OARSI (OsteoArthritis Research Society International) score for structural changes of cartilage. The number of tidemarks varied between anatomical regions respectively from 4.2 in the medial femoral condyle to 5.0 in the lateral tibial condyle. The axial part showed a significant higher number of tidemarks than the abaxial part, for all regions except the medial tibial condyle. While the tidemark count strongly correlated to age (Spearman Correlation coefficient=0.70; 95% confidence interval 0.67 to 0.73; P<0.0001), the OARSI score was weakly correlated to age in our cohort of sheep (Spearman Correlation coefficient=0.25; 95% confidence interval 0.19 to 0.30; P<0.0001). Interestingly, no tidemark was seen in the three animals aged 6 months. Our data indicate that the number of tidemarks increases with age and vary with anatomical region. The regional variation also revealed a higher number of tidemarks in the tibia than in the femur. This could be attributed to the local variation in cartilage response to strain and to the difference in chondrocyte biology and density.

    KW - sheep

    KW - cartilage

    KW - sifle

    KW - osteoarthritiss

    KW - ageing

    U2 - DOI:10.1111/ahe.12449

    DO - DOI:10.1111/ahe.12449

    M3 - Article

    JO - Anatomia, Histologia, Embryologia

    JF - Anatomia, Histologia, Embryologia

    SN - 0340-2096

    ER -