Advances in the Mechanistic Understanding of Iron Oxide Nanoparticles' Radiosensitizing Properties

Indiana Ternad; Sebastien Penninckx; Valentin Lecomte; Thomas Vangijzegem; Louise Conrard; Stéphane Lucas; Anne-Catherine Heuskin; Carine Michiels; Robert N Muller; Dimitri Stanicki; Sophie Laurent

doi:10.3390/nano13010201

Advances in the Mechanistic Understanding of Iron Oxide Nanoparticles' Radiosensitizing Properties

Indiana Ternad, Sebastien Penninckx, Valentin Lecomte, Thomas Vangijzegem, Louise Conrard, Stéphane Lucas, Anne-Catherine Heuskin, Carine Michiels, Robert N Muller, Dimitri Stanicki, Sophie Laurent

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

75 Téléchargements (Pure)

Résumé

Among the plethora of nanosystems used in the field of theranostics, iron oxide nanoparticles (IONPs) occupy a central place because of their biocompatibility and magnetic properties. In this study, we highlight the radiosensitizing effect of two IONPs formulations (namely 7 nm carboxylated IONPs and PEG 5000-IONPs) on A549 lung carcinoma cells when exposed to 225 kV X-rays after 6 h, 24 h and 48 h incubation. The hypothesis that nanoparticles exhibit their radiosensitizing effect by weakening cells through the inhibition of detoxification enzymes was evidenced by thioredoxin reductase activity monitoring. In particular, a good correlation between the amplification effect at 2 Gy and the residual activity of thioredoxin reductase was observed, which is consistent with previous observations made for gold nanoparticles (NPs). This emphasizes that NP-induced radiosensitization does not result solely from physical phenomena but also results from biological events.

langue originale	Anglais
Numéro d'article	201
journal	Nanomaterials
Volume	13
Numéro de publication	1
Les DOIs	https://doi.org/10.3390/nano13010201
Etat de la publication	Publié - 2 janv. 2023

SDG des Nations Unies

Ce résultat contribue à ou aux Objectifs de développement durable suivants

Accès au document

10.3390/nano13010201

nanomaterials-13-00201Version finale publiée, 2,08 MB

Autres fichiers et liens

Lien vers la publication sur Scopus

11 Citations
5 Article
1 Article de revue

Metallic Nanoparticles: A Useful Prompt Gamma Emitter for Range Monitoring in Proton Therapy?
Penninckx, S., Hespeels, F., Smeets, J., Colaux, J., Lucas, S. & Heuskin, A.-C., 2021, Dans: Radiation. 1, 4, p. 305-316
Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Accès ouvert
File
28 Téléchargements (Pure)
Gold nanoparticles as a potent radiosensitizer: A transdisciplinary approach from physics to patient
Penninckx, S., Heuskin, A.-C., Michiels, C. & Lucas, S., août 2020, Dans: Cancers. 12, 8, p. 1-361 361 p., 2021.
Résultats de recherche: Contribution à un journal/une revue › Article de revue › Revue par des pairs

Accès ouvert
File
78 Téléchargements (Pure)
Antibody-functionalized gold nanoparticles as tumor targeting radiosensitizers for proton therapy
Li, S., Bouchy, S., Penninckx, S., Marega, R., Fichera, O., Gallez, B., Feron, O., Martinive, P., Heuskin, A.-C., Michiels, C. & Lucas, S., 1 févr. 2019, Dans: Nanomedicine. 14, 3, p. 317-333 17 p.
Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

1 Actif

PROTHER-WAL: Proton Therapy Research in Wallonia
Michiels, C. (Responsable du Projet), Lucas, S. (Responsable du Projet), Heuskin, A.-C. (Responsable du Projet), Golli, E. (Chercheur), Coos, R. (Chercheur), Cini, N. (Chercheur), Penninckx, S. (Chercheur), Cardinal, M. (Technicien) & Henrotin, S. (Chercheur)
1/01/19 → 31/07/26
Projet: Recherche

Synthèse, Irradiation et Analyse de Matériaux (SIAM) (2016 - ...)
Louette, P. (!!Manager), Colaux, J. (!!Manager), Felten, A. (!!Manager), Tabarrant, T. (!!Operator), COME, F. (!!Operator) & Debarsy, P.-L. (!!Manager)
Plateforme technologique Synthese, irradiation et analyse des materiaux
Equipement/installations: Plateforme technolgique

Contient cette citation

@article{db56edb167cc4f06b10e20fb4ae8ca0b,

title = "Advances in the Mechanistic Understanding of Iron Oxide Nanoparticles' Radiosensitizing Properties",

abstract = "Among the plethora of nanosystems used in the field of theranostics, iron oxide nanoparticles (IONPs) occupy a central place because of their biocompatibility and magnetic properties. In this study, we highlight the radiosensitizing effect of two IONPs formulations (namely 7 nm carboxylated IONPs and PEG 5000-IONPs) on A549 lung carcinoma cells when exposed to 225 kV X-rays after 6 h, 24 h and 48 h incubation. The hypothesis that nanoparticles exhibit their radiosensitizing effect by weakening cells through the inhibition of detoxification enzymes was evidenced by thioredoxin reductase activity monitoring. In particular, a good correlation between the amplification effect at 2 Gy and the residual activity of thioredoxin reductase was observed, which is consistent with previous observations made for gold nanoparticles (NPs). This emphasizes that NP-induced radiosensitization does not result solely from physical phenomena but also results from biological events. ",

keywords = "biological mechanism, cancer therapy, iron oxide nanoparticles, radiosensitization, thioredoxin reductase, X-ray irradiation",

author = "Indiana Ternad and Sebastien Penninckx and Valentin Lecomte and Thomas Vangijzegem and Louise Conrard and St{\'e}phane Lucas and Anne-Catherine Heuskin and Carine Michiels and Muller, {Robert N} and Dimitri Stanicki and Sophie Laurent",

note = "Funding Information: The authors acknowledge the UNamur technological platform SIAM and Tijani Tabarrant for their assistance with the irradiation facilities. This work has been supported by the financial contributions of the Fond National de la Recherche Scientifique (FNRS), the ARC Programs of the French Community of Belgium, COST actions, the Walloon region (ProtherWal and Interreg projects) and the ERA-NET EuroNanoMed (THERAGET) of the EU Horizon 2020. The authors would like to thank the Center for Microscopy and Molecular Imaging (CMMI, supported by European Regional Development Fund Wallonia). Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = jan,

day = "2",

doi = "10.3390/nano13010201",

language = "English",

volume = "13",

journal = "Nanomaterials",

issn = "2079-4991",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "1",

}

TY - JOUR

T1 - Advances in the Mechanistic Understanding of Iron Oxide Nanoparticles' Radiosensitizing Properties

AU - Ternad, Indiana

AU - Penninckx, Sebastien

AU - Lecomte, Valentin

AU - Vangijzegem, Thomas

AU - Conrard, Louise

AU - Lucas, Stéphane

AU - Heuskin, Anne-Catherine

AU - Michiels, Carine

AU - Muller, Robert N

AU - Stanicki, Dimitri

AU - Laurent, Sophie

N1 - Funding Information: The authors acknowledge the UNamur technological platform SIAM and Tijani Tabarrant for their assistance with the irradiation facilities. This work has been supported by the financial contributions of the Fond National de la Recherche Scientifique (FNRS), the ARC Programs of the French Community of Belgium, COST actions, the Walloon region (ProtherWal and Interreg projects) and the ERA-NET EuroNanoMed (THERAGET) of the EU Horizon 2020. The authors would like to thank the Center for Microscopy and Molecular Imaging (CMMI, supported by European Regional Development Fund Wallonia). Publisher Copyright: © 2023 by the authors.

PY - 2023/1/2

Y1 - 2023/1/2

N2 - Among the plethora of nanosystems used in the field of theranostics, iron oxide nanoparticles (IONPs) occupy a central place because of their biocompatibility and magnetic properties. In this study, we highlight the radiosensitizing effect of two IONPs formulations (namely 7 nm carboxylated IONPs and PEG 5000-IONPs) on A549 lung carcinoma cells when exposed to 225 kV X-rays after 6 h, 24 h and 48 h incubation. The hypothesis that nanoparticles exhibit their radiosensitizing effect by weakening cells through the inhibition of detoxification enzymes was evidenced by thioredoxin reductase activity monitoring. In particular, a good correlation between the amplification effect at 2 Gy and the residual activity of thioredoxin reductase was observed, which is consistent with previous observations made for gold nanoparticles (NPs). This emphasizes that NP-induced radiosensitization does not result solely from physical phenomena but also results from biological events.

AB - Among the plethora of nanosystems used in the field of theranostics, iron oxide nanoparticles (IONPs) occupy a central place because of their biocompatibility and magnetic properties. In this study, we highlight the radiosensitizing effect of two IONPs formulations (namely 7 nm carboxylated IONPs and PEG 5000-IONPs) on A549 lung carcinoma cells when exposed to 225 kV X-rays after 6 h, 24 h and 48 h incubation. The hypothesis that nanoparticles exhibit their radiosensitizing effect by weakening cells through the inhibition of detoxification enzymes was evidenced by thioredoxin reductase activity monitoring. In particular, a good correlation between the amplification effect at 2 Gy and the residual activity of thioredoxin reductase was observed, which is consistent with previous observations made for gold nanoparticles (NPs). This emphasizes that NP-induced radiosensitization does not result solely from physical phenomena but also results from biological events.

KW - biological mechanism

KW - cancer therapy

KW - iron oxide nanoparticles

KW - radiosensitization

KW - thioredoxin reductase

KW - X-ray irradiation

UR - http://www.scopus.com/inward/record.url?scp=85145841555&partnerID=8YFLogxK

U2 - 10.3390/nano13010201

DO - 10.3390/nano13010201

M3 - Article

C2 - 36616111

SN - 2079-4991

VL - 13

JO - Nanomaterials

JF - Nanomaterials

IS - 1

M1 - 201

ER -

Advances in the Mechanistic Understanding of Iron Oxide Nanoparticles' Radiosensitizing Properties

Résumé

SDG des Nations Unies

Accès au document

Autres fichiers et liens

Empreinte digitale

Résultat de recherche

Metallic Nanoparticles: A Useful Prompt Gamma Emitter for Range Monitoring in Proton Therapy?

Gold nanoparticles as a potent radiosensitizer: A transdisciplinary approach from physics to patient

Antibody-functionalized gold nanoparticles as tumor targeting radiosensitizers for proton therapy

Projets

PROTHER-WAL: Proton Therapy Research in Wallonia

Équipement

Synthèse, Irradiation et Analyse de Matériaux (SIAM) (2016 - ...)

Contient cette citation