AAPM TG-43U1 formalism adaptation and Monte Carlo dosimetry simulations of multiple-radionuclide brachytherapy sources

V.E. Nuttens, S. Lucas

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

This paper presents a preliminary study on multiple-radionuclide sources for brachytherapy. An adaptation of the AAPM TG-43U1 formalism is proposed in order to derive the dosimetry parameters of multiple-radionuclide sources from mono-radionuclides. The adapted formalism is applied to a bi-radionuclide case with the help of Monte Carlo calculations (MCNPX 2.5.0). InterSource™ seed loaded with Pd and I was chosen. This combination promotes a higher dose rate than InterSource (loaded with I) and deeper tissue penetration than InterSource (loaded with Pd) while reducing the dose at long distance (beyond 2.5 cm) relative to InterSource. In conclusion, this work shows the benefits of combining different radionuclides inside the same seed and proposes an adaptation of the AAPM TG-43U1 formalism for the implementation of multiple-radionuclide sources in current treatment planning systems.
langue originaleAnglais
Pages (de - à)1101-1107
Nombre de pages7
journalMedical physics
Volume33
Numéro de publication4
Les DOIs
Etat de la publicationPublié - 1 avr. 2006

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