A Study of Fasoracetam's Solid State Forms: A Potential Anti-Alzheimer Pharmaceutical

Bram Harmsen, Koen Robeyns, Johan Wouters, Tom Leyssens

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

Different solid state forms of the research chemical fasoracetam, which counters the effects of Alzheimer's disease, have been subjected to a thermal and structural analysis. Single crystals were obtained from solution evaporation and from the melt. Single-crystal X-ray analyses of the crystals show the existence of 2 hydrated and 1 non-hydrated crystalline form of fasoracetam. Under ambient conditions, the hydrate form I is found to be the most stable form, showing a melting point of 57C. This low melting point, combined with possible water losses could cause problems when formulating the hydrated form and impact the storage conditions of the compound.

langueAnglais
Pages1317-1321
Nombre de pages5
journalJournal of Pharmaceutical Sciences
Volume106
Numéro5
Les DOIs
étatPublié - 1 mai 2017

Empreinte digitale

Freezing
Pharmaceutical Preparations
Alzheimer Disease
Hot Temperature
X-Rays
Water
Research

mots-clés

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    Harmsen, Bram ; Robeyns, Koen ; Wouters, Johan ; Leyssens, Tom. / A Study of Fasoracetam's Solid State Forms : A Potential Anti-Alzheimer Pharmaceutical. Dans: Journal of Pharmaceutical Sciences. 2017 ; Vol 106, Numéro 5. p. 1317-1321
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    A Study of Fasoracetam's Solid State Forms : A Potential Anti-Alzheimer Pharmaceutical. / Harmsen, Bram; Robeyns, Koen; Wouters, Johan; Leyssens, Tom.

    Dans: Journal of Pharmaceutical Sciences, Vol 106, Numéro 5, 01.05.2017, p. 1317-1321.

    Résultats de recherche: Contribution à un journal/une revueArticle

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