A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms

O. Malaspinas, A. Turjman, D. Ribeiro de Sousa, G. Garcia-Cardena, Martine Raes, P. T T Nguyen, Y. Zhang, G. Courbebaisse, C. Lelubre, K. Zouaoui Boudjeltia, B. Chopard

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

We propose a new numerical model to describe thrombus formation in cerebral aneurysms. This model combines CFD simulations with a set of bio-mechanical processes identified as being the most important to describe the phenomena at a large space and time scales. The hypotheses of the model are based on in vitro experiments and clinical observations. We document that we can reproduce very well the shape and volume of patient specific thrombus segmented in giant aneurysms.

langueAnglais
Pages68-76
Nombre de pages9
journalJournal of Theoretical Biology
Volume394
Les DOIs
étatPublié - 7 avr. 2016

Empreinte digitale

Cerebral Aneurysm
aneurysm
Spatio-temporal Model
Intracranial Aneurysm
Thrombosis
Mechanical Phenomena
CFD Simulation
Aneurysm
Numerical models
Computational fluid dynamics
Time Scales
space and time
Model
Experiment
Experiments
Observation
In Vitro Techniques

mots-clés

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    Malaspinas, O., Turjman, A., Ribeiro de Sousa, D., Garcia-Cardena, G., Raes, M., Nguyen, P. T. T., ... Chopard, B. (2016). A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms. Journal of Theoretical Biology, 394, 68-76. DOI: 10.1016/j.jtbi.2015.12.022
    Malaspinas, O. ; Turjman, A. ; Ribeiro de Sousa, D. ; Garcia-Cardena, G. ; Raes, Martine ; Nguyen, P. T T ; Zhang, Y. ; Courbebaisse, G. ; Lelubre, C. ; Zouaoui Boudjeltia, K. ; Chopard, B./ A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms. Dans: Journal of Theoretical Biology. 2016 ; Vol 394. p. 68-76
    @article{f5eb3179498a4454a69a37b4e228b756,
    title = "A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms",
    abstract = "We propose a new numerical model to describe thrombus formation in cerebral aneurysms. This model combines CFD simulations with a set of bio-mechanical processes identified as being the most important to describe the phenomena at a large space and time scales. The hypotheses of the model are based on in vitro experiments and clinical observations. We document that we can reproduce very well the shape and volume of patient specific thrombus segmented in giant aneurysms.",
    keywords = "Blood-flow, Cerebral aneurysm, Clotting, Lattice Boltzmann, Numerical modelling, Thrombosis",
    author = "O. Malaspinas and A. Turjman and {Ribeiro de Sousa}, D. and G. Garcia-Cardena and Martine Raes and Nguyen, {P. T T} and Y. Zhang and G. Courbebaisse and C. Lelubre and {Zouaoui Boudjeltia}, K. and B. Chopard",
    year = "2016",
    month = "4",
    day = "7",
    doi = "10.1016/j.jtbi.2015.12.022",
    language = "English",
    volume = "394",
    pages = "68--76",
    journal = "Journal of Theoretical Biology",
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    Malaspinas, O, Turjman, A, Ribeiro de Sousa, D, Garcia-Cardena, G, Raes, M, Nguyen, PTT, Zhang, Y, Courbebaisse, G, Lelubre, C, Zouaoui Boudjeltia, K & Chopard, B 2016, 'A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms' Journal of Theoretical Biology, VOL. 394, p. 68-76. DOI: 10.1016/j.jtbi.2015.12.022

    A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms. / Malaspinas, O.; Turjman, A.; Ribeiro de Sousa, D.; Garcia-Cardena, G.; Raes, Martine; Nguyen, P. T T; Zhang, Y.; Courbebaisse, G.; Lelubre, C.; Zouaoui Boudjeltia, K.; Chopard, B.

    Dans: Journal of Theoretical Biology, Vol 394, 07.04.2016, p. 68-76.

    Résultats de recherche: Contribution à un journal/une revueArticle

    TY - JOUR

    T1 - A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms

    AU - Malaspinas,O.

    AU - Turjman,A.

    AU - Ribeiro de Sousa,D.

    AU - Garcia-Cardena,G.

    AU - Raes,Martine

    AU - Nguyen,P. T T

    AU - Zhang,Y.

    AU - Courbebaisse,G.

    AU - Lelubre,C.

    AU - Zouaoui Boudjeltia,K.

    AU - Chopard,B.

    PY - 2016/4/7

    Y1 - 2016/4/7

    N2 - We propose a new numerical model to describe thrombus formation in cerebral aneurysms. This model combines CFD simulations with a set of bio-mechanical processes identified as being the most important to describe the phenomena at a large space and time scales. The hypotheses of the model are based on in vitro experiments and clinical observations. We document that we can reproduce very well the shape and volume of patient specific thrombus segmented in giant aneurysms.

    AB - We propose a new numerical model to describe thrombus formation in cerebral aneurysms. This model combines CFD simulations with a set of bio-mechanical processes identified as being the most important to describe the phenomena at a large space and time scales. The hypotheses of the model are based on in vitro experiments and clinical observations. We document that we can reproduce very well the shape and volume of patient specific thrombus segmented in giant aneurysms.

    KW - Blood-flow

    KW - Cerebral aneurysm

    KW - Clotting

    KW - Lattice Boltzmann

    KW - Numerical modelling

    KW - Thrombosis

    UR - http://www.scopus.com/inward/record.url?scp=84956680591&partnerID=8YFLogxK

    U2 - 10.1016/j.jtbi.2015.12.022

    DO - 10.1016/j.jtbi.2015.12.022

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    VL - 394

    SP - 68

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    JO - Journal of Theoretical Biology

    T2 - Journal of Theoretical Biology

    JF - Journal of Theoretical Biology

    SN - 0022-5193

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    Malaspinas O, Turjman A, Ribeiro de Sousa D, Garcia-Cardena G, Raes M, Nguyen PTT et al. A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms. Journal of Theoretical Biology. 2016 avr. 7;394:68-76. Disponible �, DOI: 10.1016/j.jtbi.2015.12.022