A simple synthesis of APM ([p-(N-acrylamino)-phenyl]mercuric chloride), a useful tool for the analysis of thiolated biomolecules

V Lemau de Talancé; F Bauer; D Hermand; S P Vincent

doi:10.1016/j.bmcl.2011.10.051

A simple synthesis of APM ([p-(N-acrylamino)-phenyl]mercuric chloride), a useful tool for the analysis of thiolated biomolecules

V Lemau de Talancé, F Bauer, D Hermand, S P Vincent

Résultats de recherche: Contribution à un journal/une revue › Article › Revue par des pairs

Résumé

This study describes two novel synthetic procedures to prepare APM, a useful tool for the analysis and the purification of thiolated biomolecules. The methods developed are technically simple and robust and allowed the first full characterization of pure APM. Moreover, the efficacy of APM, as a biochemical tool, was demonstrated by analysis of tRNA thiolation by APM-PAGE.

langue originale	Anglais
Pages (de - à)	7265-7
Nombre de pages	3
journal	Bioorganic & Medicinal Chemistry Letters
Volume	21
Numéro de publication	24
Les DOIs	https://doi.org/10.1016/j.bmcl.2011.10.051
Etat de la publication	Publié - 2011

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10.1016/j.bmcl.2011.10.051

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title = "A simple synthesis of APM ([p-(N-acrylamino)-phenyl]mercuric chloride), a useful tool for the analysis of thiolated biomolecules",

abstract = "This study describes two novel synthetic procedures to prepare APM, a useful tool for the analysis and the purification of thiolated biomolecules. The methods developed are technically simple and robust and allowed the first full characterization of pure APM. Moreover, the efficacy of APM, as a biochemical tool, was demonstrated by analysis of tRNA thiolation by APM-PAGE.",

author = "{Lemau de Talanc{\'e}}, V and F Bauer and D Hermand and Vincent, {S P}",

year = "2011",

doi = "10.1016/j.bmcl.2011.10.051",

language = "English",

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journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "1464-3405",

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AU - Lemau de Talancé, V

AU - Bauer, F

AU - Hermand, D

AU - Vincent, S P

PY - 2011

Y1 - 2011

N2 - This study describes two novel synthetic procedures to prepare APM, a useful tool for the analysis and the purification of thiolated biomolecules. The methods developed are technically simple and robust and allowed the first full characterization of pure APM. Moreover, the efficacy of APM, as a biochemical tool, was demonstrated by analysis of tRNA thiolation by APM-PAGE.

AB - This study describes two novel synthetic procedures to prepare APM, a useful tool for the analysis and the purification of thiolated biomolecules. The methods developed are technically simple and robust and allowed the first full characterization of pure APM. Moreover, the efficacy of APM, as a biochemical tool, was demonstrated by analysis of tRNA thiolation by APM-PAGE.

U2 - 10.1016/j.bmcl.2011.10.051

DO - 10.1016/j.bmcl.2011.10.051

M3 - Article

C2 - 22074960

SN - 1464-3405

VL - 21

SP - 7265

EP - 7267

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 24

ER -

A simple synthesis of APM ([p-(N-acrylamino)-phenyl]mercuric chloride), a useful tool for the analysis of thiolated biomolecules

Résumé

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