A Possible Infinite Number of Components in a Single Crystalline Phase: On the Isomorphism of Brivaracetam-Guest Molecules

Nicolas Couvrat, Morgane Sanselme, Yohann Cartigny, Frederic De Smet, Sandrine Rome, Luc Aerts, Luc Quéré, Johan Wouters, Gérard Coquerel

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

This article highlights the unusual behavior of brivaracetam (BRV: An active pharmaceutical ingredient against epilepsy), which leads to a unique phase-ranging from clathrate to solvate to cocrystal-formed with an impressive number of apolar guest molecules (any linear alkanes to esters of fatty acids/alcohols, or waxes). Moreover, the investigation of binary systems between linear alkanes and BRV displayed the systematic existence of a syntectic invariant (one solid melts into two nonmiscible liquids) for CnH2n+2 with n > 7.

langue originaleAnglais
Pages (de - à)4807-4810
Nombre de pages4
journalCrystal Growth and Design
Volume18
Numéro de publication9
Les DOIs
étatPublié - 5 sept. 2018

Empreinte digitale

isomorphism
Alkanes
Paraffins
alkanes
epilepsy
Crystalline materials
Paraffin waxes
Molecules
waxes
Waxes
clathrates
fatty acids
Fatty acids
ingredients
Drug products
esters
molecules
Esters
alcohols
Alcohols

Citer ceci

Couvrat, Nicolas ; Sanselme, Morgane ; Cartigny, Yohann ; De Smet, Frederic ; Rome, Sandrine ; Aerts, Luc ; Quéré, Luc ; Wouters, Johan ; Coquerel, Gérard. / A Possible Infinite Number of Components in a Single Crystalline Phase : On the Isomorphism of Brivaracetam-Guest Molecules. Dans: Crystal Growth and Design. 2018 ; Vol 18, Numéro 9. p. 4807-4810.
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Couvrat, N, Sanselme, M, Cartigny, Y, De Smet, F, Rome, S, Aerts, L, Quéré, L, Wouters, J & Coquerel, G 2018, 'A Possible Infinite Number of Components in a Single Crystalline Phase: On the Isomorphism of Brivaracetam-Guest Molecules', Crystal Growth and Design, VOL. 18, Numéro 9, p. 4807-4810. https://doi.org/10.1021/acs.cgd.8b00331

A Possible Infinite Number of Components in a Single Crystalline Phase : On the Isomorphism of Brivaracetam-Guest Molecules. / Couvrat, Nicolas; Sanselme, Morgane; Cartigny, Yohann; De Smet, Frederic; Rome, Sandrine; Aerts, Luc; Quéré, Luc; Wouters, Johan; Coquerel, Gérard.

Dans: Crystal Growth and Design, Vol 18, Numéro 9, 05.09.2018, p. 4807-4810.

Résultats de recherche: Contribution à un journal/une revueArticle

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