TY - JOUR
T1 - A pharmacophore model for sulphonyl-urea (-cyanoguanidine) compounds with dual action, thromboxane receptor antagonists and thromboxane synthase inhibitors
AU - Michaux, Catherine
AU - Dogne, Jean-Michel
AU - Rolin, Stéphanie
AU - Masereel, Bernard
AU - Wouters, Johan
AU - Durant, François
PY - 2003/7/1
Y1 - 2003/7/1
N2 - A 3D pharmacophore model was developed for original sulphonyl-urea (-cyanoguanidine) compounds and known molecules which behave both as thromboxane receptor antagonists and as thromboxane synthase inhibitors. Five recognition sites appear to be essential for this dual activity: two hydrogen bond acceptors, an anionic site, a hydrophobic group and an aromatic ring. Such a model could be used to design new leads possessing the same pharmacological profile and to improve the activity of our compounds.
AB - A 3D pharmacophore model was developed for original sulphonyl-urea (-cyanoguanidine) compounds and known molecules which behave both as thromboxane receptor antagonists and as thromboxane synthase inhibitors. Five recognition sites appear to be essential for this dual activity: two hydrogen bond acceptors, an anionic site, a hydrophobic group and an aromatic ring. Such a model could be used to design new leads possessing the same pharmacological profile and to improve the activity of our compounds.
KW - Catalyst hypothesis
KW - Pharmacophore
KW - Sulphonyl-urea (-cyanoguanidine) ligand
KW - Thromboxane receptor antagonism
KW - Thromboxane synthase inhibition
UR - http://www.scopus.com/inward/record.url?scp=0042657907&partnerID=8YFLogxK
U2 - 10.1016/S0223-5234(03)00076-X
DO - 10.1016/S0223-5234(03)00076-X
M3 - Article
C2 - 12932901
AN - SCOPUS:0042657907
SN - 0223-5234
VL - 38
SP - 703
EP - 710
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
IS - 7-8
ER -