A mannosylated pillar[5]arene derivative: Chiral information transfer and antiadhesive properties against uropathogenic bacteria

Iwona Nierengarten, Kevin Buffet, Michel Holler, Stéphane P. Vincent, Jean François Nierengarten

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

A pillar[5]arene derivative substituted with 10 peripheral acetylated mannosyl moieties has been prepared by grafting an alkynylated mannose derivative onto the macrocyclic core under the copper-catalyzed alkyne-azide cycloaddition conditions. Deacetylation of the resulting compound provided a pillar[5]arene glycocluster. NMR investigations have shown that the chiral information transfer between the different subunits of this molecule is highly sensitive to both the temperature and the solvent. Finally, the glycoconjugate has been assayed as an inhibitor of the adhesion of an uropathogenic Escherichia coli strain to red blood cells.

langue originaleAnglais
Pages (de - à)2398-2402
Nombre de pages5
journalTetrahedron Letters
Volume54
Numéro de publication19
Les DOIs
Etat de la publicationPublié - 8 mai 2013

Empreinte digitale Examiner les sujets de recherche de « A mannosylated pillar[5]arene derivative: Chiral information transfer and antiadhesive properties against uropathogenic bacteria ». Ensemble, ils forment une empreinte digitale unique.

  • Équipement

  • Contient cette citation