A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions

Carlo Yague-Sanz, Enrique Vázquez, Mar Sánchez, Francisco Antequera, Damien Hermand

Résultats de recherche: Contribution à un journal/une revueArticleRevue par des pairs

Résumé

The occupancy of nucleosomes governs access to the eukaryotic genomes and results from a combination of biophysical features and the effect of ATP-dependent remodelling complexes. Most promoter regions show a conserved pattern characterized by a nucleosome-depleted region (NDR) flanked by nucleosomal arrays. The conserved RSC remodeler was reported to be critical to establish NDR in vivo in budding yeast but other evidences suggested that this activity may not be conserved in fission yeast. By reanalysing and expanding previously published data, we propose that NDR formation requires, at least partially, RSC in both yeast species. We also discuss the most prominent biological role of RSC and the possibility that non-essential subunits do not define alternate versions of the complex.

langue originaleAnglais
Pages (de - à)1-7
Nombre de pages7
journalCurrent Genetics
Date de mise en ligne précoce24 août 2016
Les DOIs
Etat de la publicationE-pub ahead of print - 24 août 2016

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