Résumé

The study of the haemocompatibility of nanomaterials that could be in contact with blood (e.g. nanoparticle (NP)-based drug-delivery system) is of major importance. The primary objective of this study was to compare the ability of six platelet functional tests to assess the impact of NPs on platelet function. The secondary objective was to determine an accurate and reliable screening test to measure the potential impact of NPs on primary haemostasis whatever their physicochemical properties. Four types of carbon NPs (carbon black, fullerenes, single-walled carbon nanotubes and multi-walled carbon nanotubes) were investigated on six platelet function tests: light transmission aggregometry, whole-blood impedance aggregometry, platelet function analyser-100 (PFA-100®) and Cone-and-Plate(let) analyser (Impact-R®), transmission- and field emission gun scanning electron microscopy (FEG-SEM). We considered that Impact-R® supported by FEG-SEM is the reference method to investigate the potential impact of NPs on platelet function. © 2014 Informa UK, Ltd.

langue originaleAnglais
Pages (de - à)220-232
Nombre de pages13
journalNanotoxicology
Volume8
Numéro de publication2
Les DOIs
étatPublié - 1 mars 2014

Empreinte digitale

Nanostructures
Platelets
Nanostructured materials
Blood Platelets
Carbon
Carbon Nanotubes
Firearms
Electron Scanning Microscopy
Platelet Function Tests
Field emission
Fullerenes
Soot
Blood
Drug Delivery Systems
Hemostasis
Electric Impedance
Scanning electron microscopy
Nanoparticles
Single-walled carbon nanotubes (SWCN)
Light transmission

Citer ceci

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title = "A comparison of six major platelet functional tests to assess the impact of carbon nanomaterials on platelet function: A practical guide",
abstract = "The study of the haemocompatibility of nanomaterials that could be in contact with blood (e.g. nanoparticle (NP)-based drug-delivery system) is of major importance. The primary objective of this study was to compare the ability of six platelet functional tests to assess the impact of NPs on platelet function. The secondary objective was to determine an accurate and reliable screening test to measure the potential impact of NPs on primary haemostasis whatever their physicochemical properties. Four types of carbon NPs (carbon black, fullerenes, single-walled carbon nanotubes and multi-walled carbon nanotubes) were investigated on six platelet function tests: light transmission aggregometry, whole-blood impedance aggregometry, platelet function analyser-100 (PFA-100{\circledR}) and Cone-and-Plate(let) analyser (Impact-R{\circledR}), transmission- and field emission gun scanning electron microscopy (FEG-SEM). We considered that Impact-R{\circledR} supported by FEG-SEM is the reference method to investigate the potential impact of NPs on platelet function. {\circledC} 2014 Informa UK, Ltd.",
keywords = "Blood, Haemocompatibility, Impact-R, Nanoparticles, Platelets",
author = "Julie Laloy and Fran{\cc}ois Mullier and Lutfiye Alpan and {Mejia Mendoza}, {Jorge Humberto} and St{\'e}phane Lucas and Bernard Chatelain and Olivier Toussaint and Bernard Masereel and St{\'e}phanie Rolin and Jean-Michel Dogn{\'e}",
year = "2014",
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journal = "Nanotoxicology",
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AU - Chatelain, Bernard

AU - Toussaint, Olivier

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AU - Rolin, Stéphanie

AU - Dogné, Jean-Michel

PY - 2014/3/1

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AB - The study of the haemocompatibility of nanomaterials that could be in contact with blood (e.g. nanoparticle (NP)-based drug-delivery system) is of major importance. The primary objective of this study was to compare the ability of six platelet functional tests to assess the impact of NPs on platelet function. The secondary objective was to determine an accurate and reliable screening test to measure the potential impact of NPs on primary haemostasis whatever their physicochemical properties. Four types of carbon NPs (carbon black, fullerenes, single-walled carbon nanotubes and multi-walled carbon nanotubes) were investigated on six platelet function tests: light transmission aggregometry, whole-blood impedance aggregometry, platelet function analyser-100 (PFA-100®) and Cone-and-Plate(let) analyser (Impact-R®), transmission- and field emission gun scanning electron microscopy (FEG-SEM). We considered that Impact-R® supported by FEG-SEM is the reference method to investigate the potential impact of NPs on platelet function. © 2014 Informa UK, Ltd.

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