{4(S)-(Piperidin-1-ylcarbonyl)-4-[3-(trifluoromethyl)phenylsulfonamido] butyl}guanidinium chloride: A model of a graftable thrombin inhibitor

Catherine Michaux, Claudio Salvagnini, Bernadette Norberg, Jacqueline Marchand-Brynaert, Johan Wouters

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

In the title compound, C18H27F3N 5O3S+·Cl-, the guanidine group forms N-H⋯Cl hydrogen bonds, with four N⋯Cl distances in the range 3.164 (3)-3.337 (4) Å. In the crystal packing, the cations are further linked by N-H⋯O and C-H⋯O interactions. The structure is compared with that of argatroban complexed with thrombin and is the subject of docking studies in the active site of thrombin.

langue originaleAnglais
Pages (de - à)o691-o693
journalActa crystallographica Section C: Crystal Structure communications
Volume62
Numéro de publication12
Les DOIs
étatPublié - 1 déc. 2006

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