(2RS,5SR,6SR)-Methyl 4-{cis-2-[3-fluoro-5-(4-methoxy-3,4,5,6-tetrahydro-2H- pyran-4-yl)phenoxymethyl]-6-hydroxy-3-phenylmorpholino}benzenesulfinate

Caroline Charlier, Aurelie Delayen, Bernadette Norberg, Jean Pierre Hénichart, Johan Wouters

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

The title compound, C 30H 34FNO 7S, is a key intermediate in the design of dual 5-LOX (5-lipoxygenase)/COX-2 (cyclooxygenase-2) inhibitors. The compound crystallizes as a racemate. Linear hydrogen-bonded chains are aligned along the [201] direction, and stacked π-π interactions and C - H⋯O contacts stabilize the crystal structure.

langueAnglais
journalActa Crystallographica Section C: Crystal Structure Communications
Volume62
Numéro2
Les DOIs
étatPublié - 1 févr. 2006

Empreinte digitale

Arachidonate 5-Lipoxygenase
Lipoxygenase
Cyclooxygenase 2 Inhibitors
inhibitors
Hydrogen
Crystal structure
crystal structure
hydrogen
interactions
(2RS,5SR,6SR)-methyl 4-(cis-2-(3-fluoro-5-(4-methoxy-3,4,5,6-tetrahydro-2H-pyran-4-yl)phenoxymethyl)-6-hydroxy-3-phenylmorpholino)benzenesulfinate
Direction compound

Citer ceci

@article{33aed74a245d4e91ac56b5d758709e5c,
title = "(2RS,5SR,6SR)-Methyl 4-{cis-2-[3-fluoro-5-(4-methoxy-3,4,5,6-tetrahydro-2H- pyran-4-yl)phenoxymethyl]-6-hydroxy-3-phenylmorpholino}benzenesulfinate",
abstract = "The title compound, C 30H 34FNO 7S, is a key intermediate in the design of dual 5-LOX (5-lipoxygenase)/COX-2 (cyclooxygenase-2) inhibitors. The compound crystallizes as a racemate. Linear hydrogen-bonded chains are aligned along the [201] direction, and stacked π-π interactions and C - H⋯O contacts stabilize the crystal structure.",
author = "Caroline Charlier and Aurelie Delayen and Bernadette Norberg and H{\'e}nichart, {Jean Pierre} and Johan Wouters",
year = "2006",
month = "2",
day = "1",
doi = "10.1107/S0108270106001065",
language = "English",
volume = "62",
journal = "Acta Crystallographica Section C: Crystal Structure Communications",
issn = "0108-2701",
publisher = "International Union of Crystallography",
number = "2",

}

TY - JOUR

T1 - (2RS,5SR,6SR)-Methyl 4-{cis-2-[3-fluoro-5-(4-methoxy-3,4,5,6-tetrahydro-2H- pyran-4-yl)phenoxymethyl]-6-hydroxy-3-phenylmorpholino}benzenesulfinate

AU - Charlier,Caroline

AU - Delayen,Aurelie

AU - Norberg,Bernadette

AU - Hénichart,Jean Pierre

AU - Wouters,Johan

PY - 2006/2/1

Y1 - 2006/2/1

N2 - The title compound, C 30H 34FNO 7S, is a key intermediate in the design of dual 5-LOX (5-lipoxygenase)/COX-2 (cyclooxygenase-2) inhibitors. The compound crystallizes as a racemate. Linear hydrogen-bonded chains are aligned along the [201] direction, and stacked π-π interactions and C - H⋯O contacts stabilize the crystal structure.

AB - The title compound, C 30H 34FNO 7S, is a key intermediate in the design of dual 5-LOX (5-lipoxygenase)/COX-2 (cyclooxygenase-2) inhibitors. The compound crystallizes as a racemate. Linear hydrogen-bonded chains are aligned along the [201] direction, and stacked π-π interactions and C - H⋯O contacts stabilize the crystal structure.

UR - http://www.scopus.com/inward/record.url?scp=33645028381&partnerID=8YFLogxK

U2 - 10.1107/S0108270106001065

DO - 10.1107/S0108270106001065

M3 - Article

VL - 62

JO - Acta Crystallographica Section C: Crystal Structure Communications

T2 - Acta Crystallographica Section C: Crystal Structure Communications

JF - Acta Crystallographica Section C: Crystal Structure Communications

SN - 0108-2701

IS - 2

ER -