β-Selective one-pot fluorophosphorylation of d,d -heptosylglycals mediated by selectfluor

Résultats de recherche: Contribution à un journal/une revueArticle

Résumé

This study describes the development of a novel procedure of glycal fluorophosphorylation applied to the synthesis of a fluorinated analogue of an important bacterial metabolite. This procedure was applied to several heptose-derived glycals, and the stereochemical outcome of the reaction was analyzed. Under optimized conditions, the reaction is β-gluco selective, but a significant amount of the α-gluco diastereomer is also generated.

langue originaleAnglais
Pages (de - à)392-397
Nombre de pages6
journalIsrael journal of chemistry
Volume55
Numéro de publication3-4
Les DOIs
étatPublié - 1 avr. 2015

Empreinte digitale

Heptoses
Metabolites
selectfluor

Citer ceci

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title = "β-Selective one-pot fluorophosphorylation of d,d -heptosylglycals mediated by selectfluor",
abstract = "This study describes the development of a novel procedure of glycal fluorophosphorylation applied to the synthesis of a fluorinated analogue of an important bacterial metabolite. This procedure was applied to several heptose-derived glycals, and the stereochemical outcome of the reaction was analyzed. Under optimized conditions, the reaction is β-gluco selective, but a significant amount of the α-gluco diastereomer is also generated.",
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β-Selective one-pot fluorophosphorylation of d,d -heptosylglycals mediated by selectfluor. / Vincent, Stéphane; Tikad, Abdellatif.

Dans: Israel journal of chemistry, Vol 55, Numéro 3-4, 01.04.2015, p. 392-397.

Résultats de recherche: Contribution à un journal/une revueArticle

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AU - Tikad, Abdellatif

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AB - This study describes the development of a novel procedure of glycal fluorophosphorylation applied to the synthesis of a fluorinated analogue of an important bacterial metabolite. This procedure was applied to several heptose-derived glycals, and the stereochemical outcome of the reaction was analyzed. Under optimized conditions, the reaction is β-gluco selective, but a significant amount of the α-gluco diastereomer is also generated.

KW - antibiotics

KW - fluorosugars

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KW - phosphorylation

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