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Détails du projet
Description
In this project, we aim at investigating the biological basis of the neurological post-acute sequelae of COVID-19 using two experimental paradigms. In the first part, we will address the presence of autoantibodies, in the serum of long neuro-COVID patients, endowed with binding properties to central nervous system (CNS) antigens and able to impair CNS functions. Once the antibody-antigen binding has been demonstrated in vivo (in animal model) and ex vivo (on human CNS tissues), the targeted antigen.s will be identified using wide-proteome analysis. In the second part, we will study whether SARS-CoV-2 infection induces the RNA-editing mechanisms (i.e. ADAR and APOBECs enzymes known to be upregulated in epithelial cells following SARS-CoV-2 infection) in brain organoids and consequently promote the generation of neuronal-derived neoantigens. This part will include the identification of endogenous edited transcripts candidates, as well as their ability/affinity to be loaded on MHC class I molecules
Titre abrégé | Pathogenic CNS autoAb and Ag |
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statut | En cours d'exécution |
Les dates de début/date réelle | 16/01/23 → … |
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Activités
- 1 Participation à une conférence, un congrès
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Women and Girls in Science
MIGNOLET, M. (Poster)
9 févr. 2023Activité: Participation ou organisation d'un événement › Participation à une conférence, un congrès