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Résultat de recherche 1989 2017

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Article
2017

A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis

Carvalho, A., Chu, J., Meinguet, C., Kiss, R., Vandenbussche, G., Masereel, B., Wouters, J., Kornienko, A., Pelletier, J. & Mathieu, V., 15 juin 2017, Dans : European Journal of Pharmacology. 805, p. 25-35 11 p.

Résultats de recherche: Contribution à un journal/une revueArticle

norharman
Harmine
Protein Transport
Neoplasms
Protein Unfolding

Data in support of a harmine-derived beta-carboline in vitro effects in cancer cells through protein synthesis

Carvalho, A., Chu, J., Meinguet, C., Kiss, R., Vandenbussche, G., Masereel, B., Wouters, J., Kornienko, A., Pelletier, J. & Mathieu, V., 1 juin 2017, Dans : Data in Brief. 12, p. 546-551 6 p.

Résultats de recherche: Contribution à un journal/une revueArticle

norharman
Harmine
Cytostatic Agents
Protein Biosynthesis
Cell Line
2015

3D-QSAR, design, synthesis and characterization of trisubstituted harmine derivatives with in vitro antiproliferative properties

Meinguet, C., Bruyère, C., Frédérick, R., Mathieu, V., Vancraeynest, C., Pochet, L., Laloy, J., Mortier, J., Wolber, G., Kiss, R., Masereel, B. & Wouters, J., 13 avr. 2015, Dans : European Journal of Medicinal Chemistry. 94, p. 45-55 11 p., 7726

Résultats de recherche: Contribution à un journal/une revueArticle

Accès ouvert
Harmine
Quantitative Structure-Activity Relationship
Solubility
Derivatives
Cells
Silicon carbide
silicon carbides
Acute
rats
Rats
Accès ouvert
!!File
Radioimmunotherapy
Complications
Radioisotopes
Tumors
Tumor
Harmine
Cyclodextrins
Solubility
Pharmaceutical Preparations
Protons
2014
Nanostructures
Platelets
Nanostructured materials
Blood Platelets
Carbon

Can TiC nanoparticles produce toxicity in oral administration to rats?

Laloy, J., Lozano Garcia, O., Alpan, L., Mejia Mendoza, J. H., Toussaint, O., Masereel, B., Dogne, J-M. & Lucas, S., 12 mai 2014, Dans : Toxicology Reports. 1, p. 172-187 16 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Nanoparticles
Oral Administration
Toxicity
Rats
Minerals
Indoleamine-Pyrrole 2,3,-Dioxygenase
Derivatives
Scaffolds
Substitution reactions
Immunotherapy
2013

Dose assessment of SiC nanoparticle dispersions during in vitro assays

Mejia Mendoza, J. H., Piret, J-P., Noël, F., Masereel, B., Toussaint, O. & Lucas, S., 1 janv. 2013, Dans : Journal of Nanoparticle Research. 15, 8, 15 p., 1875

Résultats de recherche: Contribution à un journal/une revueArticle

culture media
Dispersions
Nanoparticles
Culture Media
Assays

Indoleamine 2,3-Dioxygenase Inhibitory Activity of Derivatives of Marine Alkaloid Tsitsikammamine A

Dolusic, E., Larrieu, P., Meinguet, C., Colette, D., Rives, A., Blanc, S., Ferain, T., Pilotte, L., Stroobant, V., Wouters, J., Van den Eynde, B., Masereel, B., Delfourne, E. & Frédérick, R., 1 janv. 2013, Dans : Bioorganic and medicinal chemistry letters. 23, 1, p. 47-54 8 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Pyrroloiminoquinones
Tryptophan Oxygenase
Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumor Escape
Antimalarials

New selective carbonic anhydrase IX inhibitors: Synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides

Rogez-Florent, T., Meignan, S., Foulon, C., Six, P., Gros, A., Bal-Mahieu, C., Supuran, C. T., Scozzafava, A., Frédérick, R., Masereel, B., Depreux, P., Lansiaux, A., Goossens, J. F., Gluszok, S. & Goossens, L., 15 mars 2013, Dans : Bioorganic and Medicinal Chemistry. 21, 6, p. 1451-1464 14 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Carbonic Anhydrase Inhibitors
Carbonic Anhydrases
Pharmacology
Doxorubicin
Carbonic Anhydrase IV
2012
Accès ouvert
!!File
Plasma deposition
Vapor deposition
Epidermal Growth Factor Receptor
Antibodies
Gold
toxicology
Toxicology
Sonication
stirring
Dispersions
Nanoparticles
Rats
X-Rays
X rays
Lung
Caco-2 Cells
Copper oxides
Hydrodynamics
Nanoparticles
Oxides
Feces
Nanoparticles
Toxicity
Rats
Chemical analysis
Accès ouvert
!!File
Dispersions
Nanoparticles
nanoparticles
Fluids
fluids

Novel trisubstituted harmine derivatives with original in vitro anticancer activity

Frédérick, R., Bruyére, C., Vancraeynest, C., Reniers, J., Meinguet, C., Pochet, L., Backlund, A., Masereel, B., Kiss, R. & Wouters, J., 26 juil. 2012, Dans : Journal of Medicinal Chemistry. 55, 14, p. 6489-6501 13 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Harmine
Carbolines
Neoplasms
Protein Synthesis Inhibitors
Cytostatic Agents
Nanoparticles
X-Rays
Food
X rays
Coffee

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

Pilotte, L., Larrieu, P., Stroobant, V., Colau, D., Dolušić, E., Frédérick, R., De Plaen, E., Uyttenhove, C., Wouters, J., Masereel, B. & Van Den Eynde, B. J., 14 févr. 2012, Dans : Proceedings of the National Academy of Sciences of the United States of America. 109, 7, p. 2497-2502 6 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Accès ouvert
!!File
Tryptophan Oxygenase
Tryptophan
Neoplasms
Indoleamine-Pyrrole 2,3,-Dioxygenase
Peripheral Tolerance

Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles

Moineaux, L., Laurent, S., Reniers, J., Dolusic, E., Galleni, M., Frère, J-M., Masereel, B., Frédérick, R. & Wouters, J., 1 août 2012, Dans : European Journal of Medicinal Chemistry. 54, p. 95-102 8 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Accès ouvert
!!File
Tryptophan Oxygenase
Indoles
Dipole moment
Isomers
Electronic properties
Nanostructures
Nanostructured materials
Thrombin
Nanoparticles
Assays
2011

Antibody immobilization on gold nanoparticles coated layer-by-layer with polyelectrolytes

Masereel, B., Dinguizli, M., Moniotte, N., Bouzin, C., Feron, O., Gallez, B., Vander Borght, T., Michiels, C. & Lucas, S., 1 avr. 2011, Dans : Journal of Nanoparticle Research. 13, 4, p. 1573-1580 8 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Polyelectrolytes
Gold Nanoparticles
antibodies
immobilization
Antibody

Anti-virulence strategy against Brucella suis: Synthesis, biological evaluation and molecular modeling of selective histidinol dehydrogenase inhibitors

Abdo, M-R., Turtaut, F., Montero, J-L., Winum, J-Y., Joseph, P., Köhler, S., Mortier, J. & Masereel, B., 21 mai 2011, Dans : Organic and Biomolecular Chemistry. 9, 10, p. 3681-3690 10 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Brucella suis
virulence
Molecular modeling
dehydrogenases
inhibitors

BM-573 inhibits the development of early atherosclerotic lesions in Apo e deficient mice by blocking TP receptors and thromboxane synthase

Cherdon, C., Ooms, A., Sakalihassan, N., Defraigne, J-O., Rolin, S., Michiels, C., Masereel, B., Dogné, J-M., Hanson, J., Pirotte, B., De Leval, L. & Drion, P. 2011 Dans : Prostaglandins and Other Lipid Mediators. 94, p. 124-132 9 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Thromboxane Receptors
Thromboxanes
Apolipoproteins E
Vascular Cell Adhesion Molecule-1
Endothelial cells

Carbon nanoparticles synthesized by sputtering and gas condensation inside a nanocluster source of fixed dimension

Bouchat, V., Feron, O., Gallez, B., Masereel, B., Michiels, C., Vander Borght, T., Rossi, F. & Lucas, S., 2011, Dans : Surface and Coatings Technology. 205, S2, p. S577-S581

Résultats de recherche: Contribution à un journal/une revueArticle

Nanoclusters
nanoclusters
Sputtering
Condensation
Carbon

Chemical reactivity of Plasma Polymerized Allylamine (PPAA) thin films on Au and Si: study of the thickness influence and ageing of the films

Moreau, N., Feron, O., Gallez, B., Masereel, B., Michiels, C., Vander Borght, T., Rossi, F. & Lucas, S. 25 juil. 2011 Dans : Surface and Coatings Technology. 205, SUPPL. 2, p. S462-S465

Résultats de recherche: Contribution à un journal/une revueArticle

Allylamine
Chemical reactivity
reactivity
Aging of materials
Amines

Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

Dolušić, E., Larrieu, P., Blanc, S., Sapunaric, F., Pouyez, J., Moineaux, L., Colette, D., Stroobant, V., Pilotte, L., Colau, D., Ferain, T., Fraser, G., Galleni, M., Frère, J-M., Masereel, B., Van Den Eynde, B., Wouters, J. & Frédérick, R., 2011, Dans : European Journal of Medicinal Chemistry. 46, 7, p. 3058-3065 8 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Indoles
Derivatives
Kinetics
Neoplasms
toxicology
Toxicology
Poloxamer
Surface structure
Sonication

Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

Dolušić, E., Larrieu, P., Blanc, S., Sapunaric, F., Norberg, B., Moineaux, L., Colette, D., Stroobant, V., Pilotte, L., Colau, D., Ferain, T., Fraser, G., Galeni, M., Frre, J. M., Masereel, B., Van Den Eynde, B., Wouters, J. & Frédérick, R., 15 févr. 2011, Dans : Bioorganic and Medicinal Chemistry. 19, 4, p. 1550-1561 12 p.

Résultats de recherche: Contribution à un journal/une revueArticle

!!File
Indoleamine-Pyrrole 2,3,-Dioxygenase
Bioactivity
Dioxygenases
Methylation
Immune System Diseases

On the use of radioisotopes to study the possible synthesis by magnetron sputtering of bimetallic nanoparticles

Bouchat, V., Moreau, N., Valembois, V., Abbas, K., Feron, O., Gallez, B., Holzwartz, U., Masereel, B., Michiels, C., Simonelli, F., Vander Borght, T. & Lucas, S. 25 août 2011 Dans : Surface and Coatings Technology. 205, 21-22, p. 4934-4940 7 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Radioisotopes
Magnetron sputtering
magnetron sputtering
Nanoparticles
nanoparticles

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation

Dubois, L., Peeters, S., Lieuwes, N. G., Geusens, N., Thiry, A., Wigfield, S., Carta, F., McIntyre, A., Scozzafava, A., Dogné, J-M., Supuran, C. T., Harris, A. L. & Masereel, B., juin 2011, Dans : Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 99, 3, p. 424-31 8 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Carbonic Anhydrase Inhibitors
Acetazolamide
Therapeutic Uses
Neoplasms
Therapeutics

Surface properties and cell adhesion onto allylamine-plasma and amine-plasma coated glass coverslips

Crespin, M., Moreau, N., Masereel, B., Feron, O., Gallez, B., Vander Borght, T., Michiels, C. & Lucas, S., mars 2011, Dans : Journal of Materials Science: Materials in Medicine. 22, 3, p. 671-682 12 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Allylamine
Surface Properties
Cell adhesion
Hydrophobic and Hydrophilic Interactions
Cell Adhesion
norharman
Monoamine Oxidase Inhibitors
Monoamine Oxidase
Harmine
Derivatives
Tryptophan Oxygenase
Indoleamine-Pyrrole 2,3,-Dioxygenase
Monoamine Oxidase
Derivatives
Substrates

Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators

Dolušić, E., Larrieu, P., Moineaux, L., Stroobant, V., Pilotte, L., Colau, D., Pochet, L., Van Den Eynde, B., Masereel, B., Wouters, J. & Frédérick, R., 11 août 2011, Dans : Journal of Medicinal Chemistry. 54, 15, p. 5320-5334 15 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Tryptophan Oxygenase
Indoles
Immunologic Factors
Tryptophan
Indoleamine-Pyrrole 2,3,-Dioxygenase
2010

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

Maresca, A., Temperini, C., Pochet, L., Masereel, B., Scozzafava, A. & Supuran, C., 2010, Dans : Journal of Medicinal Chemistry. 53, p. 335-344 10 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Coumarins
Carbonic Anhydrases
Protein Isoforms
Hydroxy Acids
Sulfonamides

Design, solid-phase synthesis and biological evaluation of novel 1,5-diarylpyrrole-3-carboxamides as carbonic anhydrase IX inhibitors

Gluszok, S., Frédérick, R., Foulon, C., Klupsch, F., Supuran, C., Vullo, D., Scozzafava, A., Goossens, J-F., Masereel, B., Depreux, P. & Goossens, L., 2010, Dans : Bioorganic and Medicinal Chemistry. 18, 21, p. 7392-7401 10 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Dispersion of multi-walled carbon nanotubes in biocompatible dispersants

Piret, J-P., Detriche, S., Vigneron, R., Vankoningsloo, S., Rolin, S., Mejia Mendoza, J. H., Masereel, B., Lucas, S., Delhalle, J., Luizi, F., Saout, C. & Toussaint, O., 2010, Dans : Journal of Nanoparticle Research. 12, 1, p. 75-82 8 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Multi-walled Carbon Nanotubes
Carbon Nanotubes
Nanotubes
Carbon nanotubes
Carbon

NF-κB inducing kinase (NIK) inhibitors: Identification of new scaffolds using virtual screening

Mortier, J., Masereel, B., Frederick, R., Remouchamps, C., Ganeff, C. & Piette, J., 1 août 2010, Dans : Bioorganic and medicinal chemistry letters. 20, 15, p. 4515-4520 6 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Scaffolds
Screening
Phosphotransferases
Rheumatoid Arthritis
Tumor Necrosis Factor Receptors

Pyrazolo[4,3-c]isoquinolines as potential inhibitors of NF-κB activation

Mortier, J., Frederick, R., Pochet, L., Wouters, J., Masereel, B., Ganeff, C., Remouchamps, C., Piette, J., Dejardin, E. & Talaga, P., 15 mai 2010, Dans : Biochemical Pharmacology. 79, 10, p. 1462-1472 11 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Isoquinolines
Chemical activation
Enzyme Inhibitors
Phosphotransferases

Radioimmunotherapy with radioactive nanoparticles: Biological doses and treatment efficiency for vascularized tumors with or without a central hypoxic area

Bouchat, V., Michiels, C., Masereel, B., Feron, O., Gallez, B., Vander Borght, T. & Lucas, S., 2010, Dans : Medical physics. 37, 4, p. 1826-1839 14 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Radioimmunotherapy
Nanoparticles
Neoplasms
Therapeutics
Radioisotopes

Structural and enzymatic study of tryptophan 2.3-dioxygenase (TDO), a potential target in anticancer immunotherapy

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J. & Frédérick, R., 2010, p. PC.355, 21st ISMC, Brussels, Belgium, September 5-9, 2010, Drugs of the Future, volume 35, issue suppl. A, pp. 217-218 2 p.

Résultats de recherche: Contribution à un événement scientifique (non publié)Article

2009

Conception et synthèse d'indanesulfonamides en tant qu'inhibiteurs originaux des anhydrases carboniques

Thiry, A., Dogné, J-M. & Masereel, B. 2009 Dans : Chimie nouvelle. 100, p. 22-25 4 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs?

Robert, S., Ghiotto, J., Pirotte, B., David, J-L., Masereel, B., Pochet, L. & Dogné, J-M. 2009 Dans : Pharmacological Research. 59, 3, p. 160-166 7 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors

Thiry, A., Ledecq, M., Cecchi, A., Frederick, R., Dogné, J. M., Supuran, C. T., Wouters, J. & Masereel, B., 15 janv. 2009, Dans : Bioorganic and Medicinal Chemistry. 17, 2, p. 553-557 5 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Carbonic Anhydrase Inhibitors
Carbonic Anhydrases
Screening
Databases
Ligands

PVD synthesis and transfer into water-based solutions of functionalized gold nanoparticles

Moreau, N., Michiels, C., Masereel, B., Feron, O., Gallez, B., Vander Borght, T. & Lucas, S. 2009 Dans : Plasma Processes and Polymers . 6, SUPPL. 1, p. S888-S892

Résultats de recherche: Contribution à un journal/une revueArticle

Physical vapor deposition
Gold
vapor deposition
gold
Nanoparticles

Synthesis and biological evaluation of a new family of anti-benzylanilinosulfonamides as CA IX inhibitors

Thiry, A., Delayen, A., Goossens, L., Houssin, R., Ledecq, M., Frankart, A., Dogné, J-M., Wouters, J., Supuran, C. T., Hénichart, J-P. & Masereel, B., 1 févr. 2009, Dans : European Journal of Medicinal Chemistry. 44, 2, p. 511-8 8 p.

Résultats de recherche: Contribution à un journal/une revueArticle

Carbonic Anhydrase II
Carbonic Anhydrase I
Carbonic Anhydrase Inhibitors
Lead compounds
Molecular modeling