%PDF-1.7
%
1 0 obj
<<
/MarkInfo <<
/Marked true
>>
/Metadata 2 0 R
/Names 3 0 R
/OpenAction [4 0 R /FitH -32768]
/Outlines 5 0 R
/PageLabels 6 0 R
/PageLayout /SinglePage
/PageMode /UseOutlines
/Pages 7 0 R
/StructTreeRoot 8 0 R
/Threads [9 0 R]
/Type /Catalog
/ViewerPreferences <<
/DisplayDocTitle true
>>
>>
endobj
10 0 obj
<<
/Author (Sophie Ayama-Canden)
/AuthoritativeDomain#5B1#5D (sciencedirect.com)
/AuthoritativeDomain#5B2#5D (elsevier.com)
/CreationDate (D:20220625102001+05'30')
/Creator (Elsevier)
/CrossMarkDomains#5B1#5D (sciencedirect.com)
/CrossMarkDomains#5B2#5D (elsevier.com)
/CrossmarkDomainExclusive (true)
/CrossmarkMajorVersionDate (2010-04-23)
/ElsevierWebPDFSpecifications (7.0)
/Keywords ("Breast cancer"; "TNBC"; "Cell migration"; "Motogenic IGDQ motif"; "Fibronectin type I"; "Integrin alpha 5"; "Integrin beta 3")
/ModDate (D:20220627074453+02'00')
/Producer (Acrobat Distiller 10.0.0 \(Windows\))
/Subject (Neoplasia, 31 \(2022\) 100816. doi:10.1016/j.neo.2022.100816)
/Title (IGDQ motogenic peptide gradient induces directional cell migration through integrin \(αv\)β3 activation in MDA-MB-231 metastatic breast cancer cells)
/doi (10.1016/j.neo.2022.100816)
/robots (noindex)
>>
endobj
2 0 obj
<<
/Length 7790
/Subtype /XML
/Type /Metadata
>>
stream
2022-06-25T10:20:01+05:30
Elsevier
2022-06-27T07:44:53+02:00
2022-06-27T07:44:53+02:00
Acrobat Distiller 10.0.0 (Windows)
"Breast cancer"; "TNBC"; "Cell migration"; "Motogenic IGDQ motif"; "Fibronectin type I"; "Integrin alpha 5"; "Integrin beta 3"
application/pdf
doi:10.1016/j.neo.2022.100816
Elsevier Inc.
Neoplasia, 31 (2022) 100816. doi:10.1016/j.neo.2022.100816
Breast cancer
TNBC
Cell migration
Motogenic IGDQ motif
Fibronectin type I
Integrin alpha 5
Integrin beta 3
IGDQ motogenic peptide gradient induces directional cell migration through integrin (αv)β3 activation in MDA-MB-231 metastatic breast cancer cells
Sophie Ayama-Canden
Rodolfo Tondo
Liliana Piñeros
Noëlle Ninane
Catherine Demazy
Marc Dieu
Antoine Fattaccioli
Tijani Tabarrant
Stéphane Lucas
Davide Bonifazi
Carine Michiels
uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c
uuid:2623302e-c496-904e-9af8-20ec9e1584fc
journal
© 2022 The Authors. Published by Elsevier Inc.
Neoplasia
1476-5586
31
10.1016/j.neo.2022.100816
https://doi.org/10.1016/j.neo.2022.100816
100816
100816
September 2022
7.0
2010-04-23
true
10.1016/j.neo.2022.100816
noindex
sciencedirect.com
elsevier.com
sciencedirect.com
elsevier.com
VoR
true
2010-04-23
10.1016/j.neo.2022.100816
sciencedirect.com
elsevier.com
True
http://creativecommons.org/licenses/by-nc-nd/4.0/
endstream
endobj
3 0 obj
<<
/Dests 11 0 R
>>
endobj
4 0 obj
<<
/Annots [12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R
22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R
32 0 R 33 0 R 34 0 R]
/B [35 0 R 36 0 R]
/Contents [37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R]
/CropBox [0 0 612.284 793.92]
/MediaBox [0 0 612.284 793.92]
/Parent 45 0 R
/Resources <<
/ExtGState <<
/GS2 46 0 R
/GS4 47 0 R
>>
/Font <<
/F1 48 0 R
/F10 49 0 R
/F11 50 0 R
/F12 51 0 R
/F2 52 0 R
/F3 53 0 R
/F4 54 0 R
/F5 55 0 R
/F6 56 0 R
/F7 57 0 R
/F8 58 0 R
/F9 59 0 R
>>
/ProcSet [/PDF /Text /ImageC /ImageB /ImageI]
/Properties <<
/MC2 60 0 R
/MC4 61 0 R
/MC5 62 0 R
>>
/XObject <<
/Im1 63 0 R
>>
>>
/Rotate 0
/StructParents 1
/Type /Page
>>
endobj
5 0 obj
<<
/Count 31
/First 64 0 R
/Last 64 0 R
>>
endobj
6 0 obj
<<
/Nums [0 65 0 R]
>>
endobj
7 0 obj
<<
/Count 16
/Kids [45 0 R 66 0 R]
/Type /Pages
>>
endobj
8 0 obj
<<
/K [67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R
77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R
87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R
97 0 R 98 0 R 99 0 R 100 0 R 101 0 R 102 0 R 103 0 R 104 0 R 105 0 R 106 0 R
107 0 R 108 0 R 109 0 R 110 0 R 111 0 R 112 0 R 113 0 R 114 0 R 115 0 R 116 0 R
117 0 R 118 0 R 119 0 R 120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R
127 0 R 128 0 R 129 0 R 130 0 R 131 0 R 132 0 R 133 0 R 134 0 R 135 0 R 136 0 R
137 0 R 138 0 R 139 0 R 140 0 R 141 0 R 142 0 R 143 0 R 144 0 R 145 0 R 146 0 R
147 0 R 148 0 R 149 0 R 150 0 R 151 0 R 152 0 R 153 0 R 154 0 R 155 0 R 156 0 R
157 0 R]
/ParentTree 158 0 R
/ParentTreeNextKey 16
/Type /StructTreeRoot
>>
endobj
9 0 obj
<<
/F 35 0 R
/I <<
/Author ()
/Keywords ()
/Subject ()
/Title (Main Text)
>>
>>
endobj
11 0 obj
<<
/Kids [159 0 R 160 0 R 161 0 R]
>>
endobj
12 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1016/j.neo.2022.100816)
>>
/Border [0 0 0]
/C [0 1 1]
/H /I
/Rect [300.084 741.873 570.978 753.366]
/Subtype /Link
/Type /Annot
>>
endobj
13 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (ntpara0010)
/H /I
/Rect [125.763 557.851 138.456 571.862]
/Subtype /Link
/Type /Annot
>>
endobj
14 0 obj
<<
/A <<
/S /URI
/URI (http://crossmark.crossref.org/dialog/?doi=10.1016/j.neo.2022.100816&domain=pdf)
>>
/Border [0 0 0]
/C [0 1 1]
/H /I
/Rect [151.116 549.524 184.104 568.686]
/Subtype /Link
/Type /Annot
>>
endobj
15 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (aff0001)
/H /I
/Rect [416.4 627.053 422.793 639.632]
/Subtype /Link
/Type /Annot
>>
endobj
16 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (aff0002)
/H /I
/Rect [495.924 627.053 502.686 639.631]
/Subtype /Link
/Type /Annot
>>
endobj
17 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (aff0001)
/H /I
/Rect [377.619 615.101 384.003 627.68]
/Subtype /Link
/Type /Annot
>>
endobj
18 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (aff0001)
/H /I
/Rect [455.532 615.101 461.916 627.68]
/Subtype /Link
/Type /Annot
>>
endobj
19 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (aff0001)
/H /I
/Rect [395.178 603.149 401.562 615.719]
/Subtype /Link
/Type /Annot
>>
endobj
20 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (aff0004)
/H /I
/Rect [454.065 603.149 460.818 615.718]
/Subtype /Link
/Type /Annot
>>
endobj
21 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (aff0001)
/H /I
/Rect [396.951 591.188 403.326 603.767]
/Subtype /Link
/Type /Annot
>>
endobj
22 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (aff0005)
/H /I
/Rect [481.074 591.188 487.449 603.767]
/Subtype /Link
/Type /Annot
>>
endobj
23 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (aff0005)
/H /I
/Rect [383.946 579.236 390.339 591.815]
/Subtype /Link
/Type /Annot
>>
endobj
24 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (aff0002)
/H /I
/Rect [467.664 579.236 474.417 591.814]
/Subtype /Link
/Type /Annot
>>
endobj
25 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (aff0003)
/H /I
/Rect [473.694 579.236 479.673 591.815]
/Subtype /Link
/Type /Annot
>>
endobj
26 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (aff0001)
/H /I
/Rect [380.598 567.275 386.964 579.854]
/Subtype /Link
/Type /Annot
>>
endobj
27 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (cor0001)
/H /I
/Rect [386.241 567.275 392.508 579.859]
/Subtype /Link
/Type /Annot
>>
endobj
28 0 obj
<<
/A <<
/S /URI
/URI (mailto:carine.michiels@unamur.be)
>>
/Border [0 0 0]
/C [0 1 1]
/H /I
/Rect [81.06 89.461 162.792 99.533]
/Subtype /Link
/Type /Annot
>>
endobj
29 0 obj
<<
/A <<
/S /URI
/URI (http://creativecommons.org/licenses/by-nc-nd/4.0/)
>>
/Border [0 0 0]
/C [0 1 1]
/H /I
/Rect [88.188 43.491 237.483 53.561]
/Subtype /Link
/Type /Annot
>>
endobj
30 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1016/j.neo.2022.100816)
>>
/Border [0 0 0]
/C [0 1 1]
/H /I
/Rect [27.195 34.518 155.682 44.597]
/Subtype /Link
/Type /Annot
>>
endobj
31 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (bib0001)
/H /I
/Rect [556.602 155.567 568.845 167.055]
/Subtype /Link
/Type /Annot
>>
endobj
32 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (bib0002)
/H /I
/Rect [371.742 100.775 392.949 112.263]
/Subtype /Link
/Type /Annot
>>
endobj
33 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (bib0006)
/H /I
/Rect [381.912 56.936 394.155 68.424]
/Subtype /Link
/Type /Annot
>>
endobj
34 0 obj
<<
/Border [0 0 0]
/C [1 0 0]
/Dest (bib0007)
/H /I
/Rect [342.591 35.021 354.834 46.509]
/Subtype /Link
/Type /Annot
>>
endobj
35 0 obj
<<
/N 36 0 R
/P 4 0 R
/R [28 134 291 176]
/T 9 0 R
/V 162 0 R
>>
endobj
36 0 obj
<<
/N 163 0 R
/P 4 0 R
/R [307 36 570 176]
/T 9 0 R
/V 35 0 R
>>
endobj
37 0 obj
<<
/Length 3046
/Filter /FlateDecode
>>
stream
HWKsﯘ#yXh
HTTJJIrskj+\R(E?`fLlVg]}v?Н\::{^n7:g设~[dtl\`R)f:{w՛?:cs.3J1!۽]Y"vVu
љb3W?ֽD5ђjSV.跋k.6d;]ʦ W:C
$.YwrM>9Ow˲@e UksJBu]I'1ٕ1j&S=9/Ӆ֣>YOs[5a4]04Mn,vv-ߖ,G^>\r=×*f"챩Ƀ%xWkX,ԧHPNSLj7>yX+s~ے.˻0IGXΏHS