Synthèse et évaluation biologique de glycoclusters contre la virulence bactérienne

  • Kevin Buffet

Student thesis: Doc typesDoctor of Sciences

Abstract

Because of the appearance of more and more bacteria resistant to antibiotics, it is an urgent need to find new antibacterials. Several approaches have developed in the last few years such as antivirulence. This strategy is based on the weakening of the bacteria rather than killing it. Therefore, we interested in this principle and we developed new antibacterials to combat the bacterial virulence. We based our approach on multivalent scaffolds, as the multivalency is well know to improve the inhibition and/or activation of biological processes. We synthesized new multimeric compounds such as glycofullerenes, glycopillararenes and glycorotaxanes. We showed that these molecules are good inhibitors of glycosyltransferases and lectins, multivalent effects were observed in several cases.
Informations complémentaires
Date of Award2 Oct 2014
Original languageFrench
Awarding Institution
  • University of Namur
SupervisorStephane Lucas (Supervisor), Davide BONIFAZI (Jury), Stephane VINCENT (Jury), Carmela APRILE (President), Jean François Nierengarten (Jury) & Sébastien GOUIN (Jury)

Cite this

'