Lysosomal storage disease and cancer
: Analysis of the consequences of GNPTAB KO in cancer cell lines:Focus on cMET, a Receptor Tyrosine Kinase

  • Manon DANCRE

Student thesis: Master typesMaster in Biomedecine, professional focus in preclinical research

Abstract

Lysosomes play an important role in the degradation and recycling of macromolecules within the cell. Lysosomal storage diseases (LSDs) can develop when lysosomes are dysfunctional, and are characterized by an overload of nondegraded material in the lysosomes. In the literature, it has been reported that these LSDs could potentially have a link with the development of cancer, with articles reporting that in several cancers, an increase in mutations of genes associated with lysosomal overload diseases could be found. In Hela cells, KO for the GNPTAB gene, which is involved in the development of a type II mucolipodosis phenotype, our team and others have demonstrated increased phosphorylation of the receptor tyrosine kinase, cMet. Knowing the involvement of this receptor (cMET) in signaling pathways promoting proliferation, migration and invasion, the study of the consequences, and the causes) of the hyperactivation of this receptor was carried out throughout this master thesis.
Date of Award16 Jan 2024
Original languageEnglish
Awarding Institution
  • University of Namur
SupervisorMarielle Boonen (Supervisor)

Keywords

  • Lysosomal Storage Disorders (LSDs)
  • Receptor Tyrosine Kinase (RTKs)
  • cMET
  • Cholesterol
  • Cancer.

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