Microemulsions are easy to prepare and very stable. They can solubilize different types of molecules and are proposed as a permeation enhancer for percutaneous drug delivery. All these characteristics have inspired scientists and they study this type of system as a possible drug vehicle in topical application. The aim of this work is to find and study a microemulsion system able to be a good drug vehicle for topical application. In order to fulfil our goal, we have studied different types of microemulsions. When they are characterized, we used these to synthesize nanoparticles by direct precipitation in the water cores of the microemulsions. Nanoparticles have been characterized by electronic microscopy, dynamic light scattering and UV visible techniques. The faculty of percutaneous permeation of these formulations have been tested by two methods (dialysis and vertical Franz cells system). Other products, including a commercially available formulation, have been tested too to compare the results and evaluate the permeation aptitude of the microemulsion systems.