Conception de nanovecteurs à base de matériaux silicatés mésoporeux hautement structurés organomodifiés pour la délivrance contrôlée de molécules médicamenteuses

Abstract

The need for decreasing the side effects related to the employment of such or such drug is further prove. The drug company is always focused on a way to decrease these harmful effects in order to guarantee the wellbeing of the patient but also of being able to benefit from it. The main aim of this thesis is to study the potentiality of mesoporous materials highly structured to fulfill the role of nanovectors for the controlled delivery of medicinal molecules in order to be able to reduce the side effects related to the use of this drug. The first part of this thesis initially approaches the synthesis of various silicate mesoporous CMI-1 matrices having various textural properties in order to study the influence of this parameter on the design of the drug. The design of SBA-15 materials was planned in order to increase the range of textural properties studied. Then, these multiple syntheses allow to optimize the immobilization of the actives molecules within these materials. To finish, the pharmacokinetic profiles, in solutions simulating the mediums gastric and intestinal, of various drugs were compared in order to determine the influence of the textural properties and the potentiality of these matrices to play the part of nanovectors. The second part treats of the functionalization of silicate mesoporous CMI-1 and SBA-15 matrices by an aminopropyl group. This allowed to reinforce the interactions Ibuprofen-matrix. The influence of this function was studied on the immobilization of Ibuprofen and the pharmacokinetic profiles of the designed drugs. The last part of this thesis is devoted to the study of the influence of an ethane function within the silicate network of PMO materials. Just like for the preceding matrices, we studied the influence of these supports on the immobilization of Ibuprofen and the pharmacokinetics profiles.

Date of Award	23 Sept 2009
Original language	French
Awarding Institution	University of Namur
Supervisor	Laurent Houssiau (Jury), Steve Lanners (President), Alexandre Leonard (Jury), Pascal Vander Voort (Jury) & BAO LIAN SU (Supervisor)