Abstract
[en] Attenuation of p53 activity appears to be a major step in Human T-lymphotropic virus type 1 (HTLV-1) Tax transformation. However, p53 genomic mutations are late and rather infrequent events in HTLV-1 induced Adult T cell leukemia (ATL). The paper by Zane et al. shows that a mediator of p53 activity, Wild-type p53-induced phosphatase 1 (Wip1), contributes to Tax-induced oncogenesis in a mouse model. Wip1 may therefore be a novel target for therapeutic approaches.
| Original language | English |
|---|---|
| Pages (from-to) | 115 |
| Number of pages | 1 |
| Journal | Retrovirology |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2012 |
| Externally published | Yes |
Keywords
- Sciences de la santé humaine => Oncologie
- HTLV-1
- Tax
- HBZ
- p53
- Wip1
- PPM1D
- MDM2
- DNA damage response
- Genomic stress
- ATM
- Chk2