WIP1 deficiency inhibits HTLV-1 Tax oncogenesis: novel therapeutic prospects for treatment of ATL?

N. Gillet, A. Carpentier, P.-Y. Barez, L. Willems

Research output: Contribution to journalArticlepeer-review

Abstract

[en] Attenuation of p53 activity appears to be a major step in Human T-lymphotropic virus type 1 (HTLV-1) Tax transformation. However, p53 genomic mutations are late and rather infrequent events in HTLV-1 induced Adult T cell leukemia (ATL). The paper by Zane et al. shows that a mediator of p53 activity, Wild-type p53-induced phosphatase 1 (Wip1), contributes to Tax-induced oncogenesis in a mouse model. Wip1 may therefore be a novel target for therapeutic approaches.
Original languageEnglish
Pages (from-to)115
Number of pages1
JournalRetrovirology
Volume9
Issue number1
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Sciences de la santé humaine => Oncologie
  • HTLV-1
  • Tax
  • HBZ
  • p53
  • Wip1
  • PPM1D
  • MDM2
  • DNA damage response
  • Genomic stress
  • ATM
  • Chk2

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