Several direct oral anticoagulants (DOACs) are now widely used in the prevention and treatment of thromboembolic events. Unlike vitamin K antagonists, DOACs exhibit predictable pharmacokinetics and pharmacodynamics. DOACs are to be administered at fixed doses without routine coagulation monitoring. However, in some patient populations or specific clinical circumstances, measurement of drug exposure may be useful, such as in suspected overdose, in patients with a haemorrhagic or thromboembolic event during treatment with an anticoagulant, in those with acute renal failure, or in patients who require urgent surgery. This article provides practical guidance on laboratory testing of DOACs in routine practice and summarizes the influence of DOACs on commonly used coagulation assays.
|Translated title of the contribution||Why, when and how monitor new oral anticoagulants?|
|Number of pages||8|
|Journal||Revue médicale suisse|
|Publication status||Published - 5 Feb 2014|
- Administration, Oral
- Blood Coagulation Tests
- Drug Monitoring
- Kidney Failure, Chronic
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Douxfils, J., 24 Oct 2015
Supervisor: Dogne, J. (Supervisor), Mullier, F. (Supervisor), Masereel, B. (President), Chatelain, B. (Jury), Chatelain, C. (External person) (Jury), Verhamme, P. B. (External person) (Jury), TEN CATE, H. (External person) (Jury) & Ageno, W. (External person) (Jury)
Student thesis: Doc types › Doctor of Biomedical and Pharmaceutical Sciences