Versatile access to benzhydryl-phenylureas through an unexpected rearrangement during microwave-enhanced synthesis of hydantoins

Giulio G. Muccioli, Johan Wouters, Jacques H. Poupaert, Bernadette Norberg, Wolfgang Poppitz, Gerhard K E Scriba, Didier M. Lambert

Research output: Contribution to journalArticle


(Equation presented) A new access to benzhydryl-phenylureas is described. These new interesting urea derivatives were obtained by reaction of substituted benzils with substituted phenylureas under microwave irradiation. Phenylthiourea, when reacted with benzil, gave 3-phenyl-thiohydantoin. Moreover, benzylurea, as phenethylurea, gave the corresponding 3-substituted hydantoin derivatives, demonstrating that only phenylurea derivatives can result in benzhydryl-phenylureas under the applied conditions. This new reaction proved to be an easy access to substituted 1-benzhydryl-3-phenyl-ureas.

Original languageEnglish
Pages (from-to)3599-3602
Number of pages4
JournalOrganic Letters
Issue number20
Publication statusPublished - 2 Oct 2003


Cite this