UV, stress and aging

Florence Debacq-Chainiaux; Cedric Leduc; Alix Verbeke; Olivier Toussaint

doi:10.4161/derm.23652

UV, stress and aging

Florence Debacq-Chainiaux, Cedric Leduc, Alix Verbeke, Olivier Toussaint

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Abstract

Skin is a model of choice in studies on aging. Indeed, skin aging can be modulated by internal and external factors, reflecting its complexity. Two types of skin aging have been identified: intrinsic, mainly genetically determined and extrinsic-also called "photo-aging"-resulting on the impact of environmental stress and more precisely of UV rays. Simplified in vitro models, based on cellular senescence, have been developed to study the relationship between UV and aging. These models vary on the cell type (fibroblasts or keratinocytes, normal or immortalized) and the type of UV used (UVA or UVB).

Original language	English
Pages (from-to)	236-40
Number of pages	5
Journal	Dermato-endocrinology
Volume	4
Issue number	3
DOIs	https://doi.org/10.4161/derm.23652
Publication status	Published - 1 Jul 2012

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UV, stress and aging

Abstract

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