Upregulation of annexin A2 in H2O2-induced premature senescence as evidenced by 2D-DIGE proteome analysis

Aline Chrétien, Edouard Delaive, Marc Dieu, Catherine Demazy, Noëlle Ninane, Martine Raes, Olivier Toussaint

Research output: Contribution to journalArticlepeer-review


Human diploid fibroblasts undergo premature senescence after treatment with sublethal concentration of H2O2. We report the first proteomic study of microsomal proteins in the context of H2O2-induced premature senescence by using 2D-DIGE approach. Twelve different proteins with altered abundance at day 3 after treatment with H2O2 were identified. Among them, we demonstrated a re-localization of annexin A2 in plasma membrane. © 2008 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)353-359
Number of pages7
JournalExperimental Gerontology
Issue number4
Publication statusPublished - Apr 2008


  • Annexin
  • Fibroblasts
  • HO
  • Membrane
  • Proteomics
  • Senescence


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