Type III secretion: the bacteria-eukaryotic cell express

Luís Jaime Mota, Isabel Sorg, Guy R Cornelis

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Type III secretion (T3S) is an export pathway used by Gram-negative pathogenic bacteria to inject bacterial proteins into the cytosol of eukaryotic host cells. This pathway is characterized by (i) a secretion nanomachine related to the bacterial flagellum, but usually topped by a stiff needle-like structure; (ii) the assembly in the eukaryotic cell membrane of a translocation pore formed by T3S substrates; (iii) a non-cleavable N-terminal secretion signal; (iv) T3S chaperones, assisting the secretion of some substrates; (v) a control mechanism ensuring protein delivery at the right place and time. Here, we review these different aspects focusing in open questions that promise exciting findings in the near future.
    Original languageEnglish
    Pages (from-to)1-10
    Number of pages10
    JournalFEMS microbiology letters
    Volume252
    Issue number1
    DOIs
    Publication statusPublished - 2005

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