Tumor-infiltrating lymphocytes: Apparently good for melanoma patients. but why?

Arcadi Cipponi, Grégoire Wieers, Nicolas Van Baren, Pierre G. Coulie

Research output: Contribution to journalReview articlepeer-review


Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical benefit from the vaccines. In this context, we review results pertaining to TILs in human melanomas, their prognostic value, and some possible reasons why their presence could help in selecting melanoma patients for vaccination against tumor-specific antigens.

Original languageEnglish
Pages (from-to)1153-1160
Number of pages8
JournalCancer Immunology, Immunotherapy
Issue number8
Publication statusPublished - Aug 2011
Externally publishedYes


  • Immunotherapy
  • Melanoma
  • PIVAC 10
  • Prognosis
  • T lymphocyte


Dive into the research topics of 'Tumor-infiltrating lymphocytes: Apparently good for melanoma patients. but why?'. Together they form a unique fingerprint.

Cite this