Tumor-infiltrating lymphocytes: Apparently good for melanoma patients. but why?

Arcadi Cipponi; Grégoire Wieërs; Nicolas Van Baren; Pierre G. Coulie

doi:10.1007/s00262-011-1026-2

Tumor-infiltrating lymphocytes: Apparently good for melanoma patients. but why?

Arcadi Cipponi, Grégoire Wieërs, Nicolas Van Baren, Pierre G. Coulie

Research output: Contribution to journal › Review article › peer-review

Abstract

Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical benefit from the vaccines. In this context, we review results pertaining to TILs in human melanomas, their prognostic value, and some possible reasons why their presence could help in selecting melanoma patients for vaccination against tumor-specific antigens.

Original language	English
Pages (from-to)	1153-1160
Number of pages	8
Journal	Cancer Immunology, Immunotherapy
Volume	60
Issue number	8
DOIs	https://doi.org/10.1007/s00262-011-1026-2
Publication status	Published - Aug 2011
Externally published	Yes

Keywords

Immunotherapy
Melanoma
PIVAC 10
Prognosis
T lymphocyte

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00262-011-1026-2

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title = "Tumor-infiltrating lymphocytes: Apparently good for melanoma patients. but why?",

abstract = "Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical benefit from the vaccines. In this context, we review results pertaining to TILs in human melanomas, their prognostic value, and some possible reasons why their presence could help in selecting melanoma patients for vaccination against tumor-specific antigens.",

keywords = "Immunotherapy, Melanoma, PIVAC 10, Prognosis, T lymphocyte",

author = "Arcadi Cipponi and Gr{\'e}goire Wie{\"e}rs and {Van Baren}, Nicolas and Coulie, {Pierre G.}",

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AU - Cipponi, Arcadi

AU - Wieërs, Grégoire

AU - Van Baren, Nicolas

AU - Coulie, Pierre G.

PY - 2011/8

Y1 - 2011/8

N2 - Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical benefit from the vaccines. In this context, we review results pertaining to TILs in human melanomas, their prognostic value, and some possible reasons why their presence could help in selecting melanoma patients for vaccination against tumor-specific antigens.

AB - Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments suggested that the presence of T cells in metastatic melanomas before vaccinating the patients with tumor antigens could be a biomarker for clinical benefit from the vaccines. In this context, we review results pertaining to TILs in human melanomas, their prognostic value, and some possible reasons why their presence could help in selecting melanoma patients for vaccination against tumor-specific antigens.

KW - Immunotherapy

KW - Melanoma

KW - PIVAC 10

KW - Prognosis

KW - T lymphocyte

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Tumor-infiltrating lymphocytes: Apparently good for melanoma patients. but why?

Abstract

Keywords

UN SDGs

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Absence of recognition of common melanocytic antigens by T cells isolated from the cerebrospinal fluid of a Vogt-Koyanagi-Harada patient

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