Traumatic brain injury impairs small-world topology

Anand S. Pandit, Paul Expert, Renaud Lambiotte, Valerie Bonnelle, Robert Leech, Federico E. Turkheimer, David J. Sharp

Research output: Contribution to journalArticle

Abstract

Objective: We test the hypothesis that brain networks associated with cognitive function shift away from a "small-world" organization following traumatic brain injury (TBI). Methods: We investigated 20 TBI patients and 21 age-matched controls. Resting-state functional MRI was used to study functional connectivity. Graph theoretical analysis was then applied to partial correlation matrices derived from these data. The presence of white matter damage was quantified using diffusion tensor imaging. Results: Patients showed characteristic cognitive impairments as well as evidence of damage to white matter tracts. Compared to controls, the graph analysis showed reduced overall connectivity, longer average path lengths, and reduced network efficiency. A particular impact of TBI is seen on a major network hub, the posterior cingulate cortex. Taken together, these results confirm that a network critical to cognitive function shows a shift away from small-world characteristics. Conclusions: We provide evidence that key brain networks involved in supporting cognitive function become less small-world in their organization after TBI. This is likely to be the result of diffuse white matter damage, and may be an important factor in producing cognitive impairment after TBI. © 2013 American Academy of Neurology.

Original languageEnglish
Pages (from-to)1826-1833
Number of pages8
JournalNeurology
Volume80
Issue number20
DOIs
Publication statusPublished - 14 May 2013

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Cognition
Diffusion Tensor Imaging
Gyrus Cinguli
Brain
Magnetic Resonance Imaging
Traumatic Brain Injury
Topology
White Matter
Damage
Cognitive Function
Cognitive Dysfunction
Connectivity
Graph
Cognitive Impairment
Length
Cortex
Functional MRI
Imaging

Cite this

Pandit, A. S., Expert, P., Lambiotte, R., Bonnelle, V., Leech, R., Turkheimer, F. E., & Sharp, D. J. (2013). Traumatic brain injury impairs small-world topology. Neurology, 80(20), 1826-1833. https://doi.org/10.1212/WNL.0b013e3182929f38
Pandit, Anand S. ; Expert, Paul ; Lambiotte, Renaud ; Bonnelle, Valerie ; Leech, Robert ; Turkheimer, Federico E. ; Sharp, David J. / Traumatic brain injury impairs small-world topology. In: Neurology. 2013 ; Vol. 80, No. 20. pp. 1826-1833.
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Pandit, AS, Expert, P, Lambiotte, R, Bonnelle, V, Leech, R, Turkheimer, FE & Sharp, DJ 2013, 'Traumatic brain injury impairs small-world topology', Neurology, vol. 80, no. 20, pp. 1826-1833. https://doi.org/10.1212/WNL.0b013e3182929f38

Traumatic brain injury impairs small-world topology. / Pandit, Anand S.; Expert, Paul; Lambiotte, Renaud; Bonnelle, Valerie; Leech, Robert; Turkheimer, Federico E.; Sharp, David J.

In: Neurology, Vol. 80, No. 20, 14.05.2013, p. 1826-1833.

Research output: Contribution to journalArticle

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Pandit AS, Expert P, Lambiotte R, Bonnelle V, Leech R, Turkheimer FE et al. Traumatic brain injury impairs small-world topology. Neurology. 2013 May 14;80(20):1826-1833. https://doi.org/10.1212/WNL.0b013e3182929f38