Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture

Thi Kim Duy Vo, Marie de Saint-Hubert, Gabriel Morrhaye, Patrice Godard, Vincent Geenen, Henri J. Martens, Florence Debacq-Chainiaux, Christian Swine, Olivier Toussaint

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Abstract

The abundance of a preselection of transcripts involved in inflammation, immunosenescence and stress response was compared between PBMC of healthy aged donors and aged patients in acute phase of heart failure and at recovery. This study identified 22 transcripts differentially abundant in acute phase of heart failure versus healthy aged subjects. Transcripts involved in inflammation and oxidative stress were more abundant. Those associated with T-cell functions were less abundant. The results were compared to two other major acute geriatric issues: infectious diseases and hip fracture. In acute phase, compared to healthy aged subjects, the abundance of 15/22 transcripts was also altered in both geriatric infectious diseases and hip fracture. Many variations had not vanished at the recovery phase. The abundance of CD28, CD69, LCK, HMOX1, TNFRSF1A transcripts, known to be altered in healthy aged versus healthy young subjects, was further affected in acute phase of the three geriatric diseases considered. The transcript levels of BCL2, CASP8, CCL5, DDIT3, EGR3, IL10RB, IL1R2, SERPINB2 and TIMP1 were affected in all three pathological conditions compared to healthy aged, but not versus healthy young subjects. In conclusion, this work provides critical targets for therapeutic research on geriatric heart failure, infectious diseases and hip fracture. © 2011 Elsevier Ireland Ltd.

Original languageEnglish
Pages (from-to)131-139
Number of pages9
JournalMechanisms of Ageing and Development
Volume132
Issue number3
DOIs
Publication statusPublished - 1 Mar 2011

Keywords

  • Ageing
  • Gene expression
  • Heart failure
  • Immunosenescence
  • Inflammation
  • Oxidative stress

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