TLR2 and TLR4 activate p38 MAPK and JNK during endurance exercise in skeletal muscle

Hermann Zbinden-Foncea; Jean-Marc Raymackers; Louise Deldicque; Patricia Renard; Marc Francaux

doi:10.1249/MSS.0b013e31824e0d5d

TLR2 and TLR4 activate p38 MAPK and JNK during endurance exercise in skeletal muscle

Hermann Zbinden-Foncea, Jean-Marc Raymackers, Louise Deldicque, Patricia Renard, Marc Francaux

Research output: Contribution to journal › Article › peer-review

Abstract

Toll-like receptors 2 and 4 (TLR2, TLR4) are found in the membrane of skeletal muscle cells. A variety of molecular components can activate TLR2 and TLR4, among others, long-chain fatty acids. The subsequent downstream signaling triggers the mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) pathways. Therefore, the purpose of this study was to test whether an elevation of extracellular nonesterified fatty acids (NEFA) observed during endurance exercise may activate the MAPK and NF-κB pathways via TLR2 and TLR4.

Original language	English
Pages (from-to)	1463-72
Number of pages	10
Journal	Medicine and science in sports and exercise
Volume	44
Issue number	8
DOIs	https://doi.org/10.1249/MSS.0b013e31824e0d5d
Publication status	Published - Aug 2012

Keywords

Animals
NF-kappa B
Mice
Toll-Like Receptor 2
Muscle, Skeletal
Toll-Like Receptor 4
Blotting, Western
MAP Kinase Signaling System
p38 Mitogen-Activated Protein Kinases
Fatty Acids, Nonesterified
Physical Exertion
Mice, Inbred C57BL
Physical Conditioning, Animal
Male
Signal Transduction

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Cite this

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title = "TLR2 and TLR4 activate p38 MAPK and JNK during endurance exercise in skeletal muscle",

abstract = "Toll-like receptors 2 and 4 (TLR2, TLR4) are found in the membrane of skeletal muscle cells. A variety of molecular components can activate TLR2 and TLR4, among others, long-chain fatty acids. The subsequent downstream signaling triggers the mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) pathways. Therefore, the purpose of this study was to test whether an elevation of extracellular nonesterified fatty acids (NEFA) observed during endurance exercise may activate the MAPK and NF-κB pathways via TLR2 and TLR4.",

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author = "Hermann Zbinden-Foncea and Jean-Marc Raymackers and Louise Deldicque and Patricia Renard and Marc Francaux",

year = "2012",

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language = "English",

volume = "44",

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T1 - TLR2 and TLR4 activate p38 MAPK and JNK during endurance exercise in skeletal muscle

AU - Zbinden-Foncea, Hermann

AU - Raymackers, Jean-Marc

AU - Deldicque, Louise

AU - Renard, Patricia

AU - Francaux, Marc

PY - 2012/8

Y1 - 2012/8

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AB - Toll-like receptors 2 and 4 (TLR2, TLR4) are found in the membrane of skeletal muscle cells. A variety of molecular components can activate TLR2 and TLR4, among others, long-chain fatty acids. The subsequent downstream signaling triggers the mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) pathways. Therefore, the purpose of this study was to test whether an elevation of extracellular nonesterified fatty acids (NEFA) observed during endurance exercise may activate the MAPK and NF-κB pathways via TLR2 and TLR4.

KW - Animals

KW - NF-kappa B

KW - Mice

KW - Toll-Like Receptor 2

KW - Muscle, Skeletal

KW - Toll-Like Receptor 4

KW - Blotting, Western

KW - MAP Kinase Signaling System

KW - p38 Mitogen-Activated Protein Kinases

KW - Fatty Acids, Nonesterified

KW - Physical Exertion

KW - Mice, Inbred C57BL

KW - Physical Conditioning, Animal

KW - Male

KW - Signal Transduction

U2 - 10.1249/MSS.0b013e31824e0d5d

DO - 10.1249/MSS.0b013e31824e0d5d

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SN - 1530-0315

VL - 44

SP - 1463

EP - 1472

JO - Medicine and science in sports and exercise

JF - Medicine and science in sports and exercise

IS - 8

ER -

TLR2 and TLR4 activate p38 MAPK and JNK during endurance exercise in skeletal muscle

Abstract

Keywords

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