The Yersinia yop regulon

G R Cornelis, T Biot, C Lambert de Rouvroit, T Michiels, B Mulder, C Sluiters, M P Sory, M Van Bouchaute, J C Vanooteghem

Research output: Contribution to journalArticlepeer-review


Growth of yersiniae is restricted at 37 degrees C in the absence of calcium ions. This phenomenon correlates with the massive release of a set of proteins called Yops. Growth restriction and Yops production are governed by a 70 kb plasmid called pYV. yop genes are distributed throughout pYV and constitute a thermoactivated regulon controlled by the gene virF. The transcription activator VirF is a member of a new family of regulators including those of the arabinose and rhamnose operons as well as a regulator of enteric colonization pili. The role of calcium ions on the release of Yops remains largely unknown.
Original languageEnglish
Pages (from-to)1455-9
Number of pages5
JournalMolecular Microbiology
Issue number10
Publication statusPublished - 1989


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