TY - JOUR
T1 - The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles
AU - Mueller, Catherine A
AU - Broz, Petr
AU - Müller, Shirley A
AU - Ringler, Philippe
AU - Erne-Brand, Françoise
AU - Sorg, Isabel
AU - Kuhn, Marina
AU - Engel, Andreas
AU - Cornelis, Guy R
PY - 2005
Y1 - 2005
N2 - Many pathogenic bacteria use injectisomes to deliver effector proteins into host cells through type III secretion. Injectisomes consist of a basal body embedded in the bacterial membranes and a needle. In Yersinia, translocation of effectors requires the YopB and YopD proteins, which form a pore in the target cell membrane, and the LcrV protein, which assists the assembly of the pore. Here we report that LcrV forms a distinct structure at the tip of the needle, the tip complex. This unique localization of LcrV may explain its crucial role in the translocation process and its efficacy as the main protective antigen against plague.
AB - Many pathogenic bacteria use injectisomes to deliver effector proteins into host cells through type III secretion. Injectisomes consist of a basal body embedded in the bacterial membranes and a needle. In Yersinia, translocation of effectors requires the YopB and YopD proteins, which form a pore in the target cell membrane, and the LcrV protein, which assists the assembly of the pore. Here we report that LcrV forms a distinct structure at the tip of the needle, the tip complex. This unique localization of LcrV may explain its crucial role in the translocation process and its efficacy as the main protective antigen against plague.
U2 - 10.1126/science.1118476
DO - 10.1126/science.1118476
M3 - Article
C2 - 16254184
SN - 1095-9203
VL - 310
SP - 674
EP - 676
JO - Science (New York, N.Y.)
JF - Science (New York, N.Y.)
IS - 5748
ER -